Acute lymphoblastic leukemia with maturation--a new entity with clinical significance

Leukemia
Y KimK Han

Abstract

The diagnosis of 'ALL with maturation' (ALLm) is proposed. One hundred and one patients with untreated ALL were entered into this study. The diagnosis of ALLm was made when more than 20% of all nucleated elements in the bone marrow showed maturation beyond prolymphocytes by light microscopic examination. The mature-appearing leukemic cells showed the same immunophenotype to remaining lymphoblasts. The number of ALLm cases was 19 (18.8%). The mean age at presentation of ALLm was 29 +/- 18, older than that of 18 +/- 16 of the remaining typical ALL (ALLt) (P = 0.015). Remission was induced with daunorubicin, vincristine, prednisone and L-asparaginase. Only two of 19 ALLm patients achieved CR after 4 weeks induction chemotherapy. In contrast, 57 of 82 (69.5%) ALLt patients achieved CR after the same induction chemotherapy. There was no significant difference in immunophenotype of ALLm compared with ALLt. Labeling index of DNA topoisomerase IIalpha (TopoLI) was studied by immunohistochemistry. Initial TopoLI of ALLm (221 +/- 147) was much lower than that of ALLt (609 +/- 262, P = 0.005). Furthermore, the remaining leukemic cells after chemotherapy were not labeled with anti-DNA topoisomerase IIalpha. The P53 protein was expressed in...Continue Reading

Citations

Apr 14, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Fei YangZhiyong Guo
Jul 15, 2000·Archives of Pharmacal Research·H M KimH Huh
Nov 22, 2008·Archives of Pharmacal Research·Hwan Mook KimSang-Bae Han
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze

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