Acute lymphoblastic leukemia with hypereosinophilia and 9p21 deletion: case report and review of the literature

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
Guido D'AngeloPaolo Todeschin

Abstract

Acute lymphoblastic leukemia (ALL) associated with eosinophilia is very rare, with approximately 44 reported cases. We are reporting this case not only because of the rarity of ALL with peripheral blood eosinophilia, but also because we observed a homozygous deletion of the 9p21 locus corresponding to the p16 gene, a cytogenetic abnormality that was not reported in other documented cases. ALL with eosinophilia must be considered a distinct clini-copathologic entity. It is very important for clinicians to be aware of this specific manifestation of ALL within the context of a persistent peripheral eosinophilia, particularly if no lymphoblasts are present in the peripheral blood.

Citations

Feb 2, 2013·Archives of Pathology & Laboratory Medicine·Nathan D MontgomeryYuri D Fedoriw
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Hiroto KanekoMasafumi Taniwaki
Oct 20, 2010·British Journal of Haematology·Maria Cristina RapanottiFrancesco Lo-Coco
Apr 6, 2018·BioMed Research International·Giuseppe A RamirezLorenzo Dagna
May 20, 2009·International Journal of Laboratory Hematology·C Briggs
Jul 23, 2013·The American Journal of Case Reports·Azim RezamandNariman Nezami
Sep 21, 2018·Frontiers in Immunology·Justin T Schwartz, Patricia C Fulkerson
Jul 3, 2021·International Journal of Molecular Sciences·José M Rodrigo-MuñozVictoria Del Pozo

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