PMID: 6950203Jan 1, 1982

Acute lymphocytic leukemia with microblastosis and near haploidy (26 chromosomes): a case report

Medical and Pediatric Oncology
G A HoeltgeM L Slovak

Abstract

A three-year-old acute lymphocytic leukemia (ALL) patient had a modal chromosome count of 26 in her bone marrow metaphases. The leukemia was "common" ALL by cytochemical and immunologic studies. Five other cases had been reported previously, and all have had a near haploidy varying from 26 to 32 chromosomes. Disomy of chromosomes 18 and 21 is a consistent feature of this disease. Severe hypodiploidy correlates with microblastosis requiring morphologic separation from non-neoplastic small lymphocytes.

Citations

Nov 1, 1989·Indian Journal of Pediatrics·R AbeS Kariyone
Mar 15, 1985·Cancer Genetics and Cytogenetics·S MisawaJ R Testa
Jan 15, 1986·Cancer Genetics and Cytogenetics·U KristofferssonF Mitelman
Apr 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·A A Sandberg
Aug 1, 1993·American Journal of Hematology·S WidellP Reizenstein
Jan 1, 1988·Leukemia Research·R S VermaM Coleman
Jan 1, 1988·Pediatric Hematology and Oncology·I NordensonE Forestier

Related Concepts

Marrow
Chromosomes, Human,16-18
Chromosomes, Human,21-22
Diploid Cell
Haploid Cell
Karyotype Determination Procedure
Lymphoid Leukemia
Lymphoid Cells
Metaphase

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