Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography

The British Journal of Ophthalmology
G CasalinoMaurizio Battaglia Parodi

Abstract

To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions using enface OCT images of photoreceptors-retinal pigment epithelium complex was used to discriminate intralesional and extralesional regions on the OCT-A enface slabs of the DCP and CC reconstructions. Each OCT-A slab was imported into ImageJ V.1.50 and digitally binarised for quantitative analyses. Overall, seven patients (mean age 19.4±3.2 years, six women) affected by AMN were included. The mean best-corrected visual acuity was 0.00±0.00 logarithm of the minimum angle of resolution. Twelve healthy age-matched subjects (mean age 22±3.4 years, 10 women) represented the control group. The quantitative analysis of global v...Continue Reading

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Citations

May 30, 2019·Journal of Ophthalmic Inflammation and Infection·Vita L S DingerkusMatthias Becker
Jul 31, 2020·The British Journal of Ophthalmology·Francesco PichiMarion R Munk
Nov 8, 2019·Ocular Immunology and Inflammation·Imran AshfaqAndrew C Browning
Dec 18, 2019·BMJ Case Reports·Neha GuptaAsheesh Tewari
Sep 22, 2020·Journal of Ophthalmic Inflammation and Infection·Scott Joseph Sonne, Bradley Thomas Smith
Dec 10, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A SimbrunnerA Abri
Sep 13, 2019·Progress in Retinal and Eye Research·Francesco PichiMarion R Munk
Mar 7, 2021·Journal of Clinical Medicine·Hiroto TerasakiTaiji Sakamoto
Aug 14, 2020·Progress in Retinal and Eye Research·Jackson ScharfDavid Sarraf
May 28, 2021·Acta Ophthalmologica·Clarice GiacuzzoAki Kawasaki
Apr 30, 2021·Indian Journal of Ophthalmology·Mallika GoyalSridhar Annum
Jul 1, 2021·Ocular Immunology and Inflammation·Manuela MambrettiGiuseppe Casalino
Jul 21, 2021·American Journal of Ophthalmology·Claudio IovinoDavid Sarraf

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