Acute marijuana effects on response-reinforcer relations under multiple variable-interval schedules

Behavioural Pharmacology
Scott D LaneO V Tcheremissine

Abstract

Acute marijuana administration may alter response-reinforcer relationships via a change in reinforcer efficacy, but may also impair coordination and motor function. One approach to evaluating drug effects on both motor function and reinforcer efficacy involves fitting the matching law equation to data obtained under multiple variable interval (VI) schedules. The present report describes an experiment that examined the effects of acute marijuana on response properties using this approach. Six human subjects responded under a multiple VI schedule for monetary reinforcers after smoking placebo and two active doses of marijuana. The low marijuana dose produced unsystematic changes in responding. As measured by the matching law equation parameters (k and rB), at the high dose five subjects showed a decrease-motor-related properties of response rate and four subjects' responding indicated a decrease in reinforcer efficacy. These data raise the possibility that, at high doses, marijuana administration alters both motor function and reinforcer efficacy.

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Citations

Nov 2, 2013·Journal of Psychoactive Drugs·Michael SchererDebra Furr-Holden
Apr 4, 2014·Psychopharmacology·Michael A P BloomfieldOliver D Howes
Feb 10, 2016·Biological Psychiatry·Samantha J BroydNadia Solowij
Apr 19, 2005·Addictive Behaviors·Scott D LaneJoel L Steinberg
Aug 26, 2006·Addictive Behaviors·Scott D LaneJennifer L Sharon
Jan 13, 2015·Drug and Alcohol Dependence·Jodi M GilmanA Eden Evins
Nov 8, 2005·Journal of Psychopharmacology·Oleg V TcheremissineDon R Cherek
Sep 16, 2016·Psychological Medicine·M A P BloomfieldO D Howes

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