Acute maternal stress in pregnancy and schizophrenia in offspring: a cohort prospective study.

BMC Psychiatry
D MalaspinaS Harlap

Abstract

Schizophrenia has been linked with intrauterine exposure to maternal stress due to bereavement, famine and major disasters. Recent evidence suggests that human vulnerability may be greatest in the first trimester of gestation and rodent experiments suggest sex specificity. We aimed to describe the consequence of an acute maternal stress, through a follow-up of offspring whose mothers were pregnant during the Arab-Israeli war of 1967. A priori, we focused on gestational month and offspring's sex. In a pilot study linking birth records to Israel's Psychiatric Registry, we analyzed data from a cohort of 88,829 born in Jerusalem in 1964-76. Proportional hazards models were used to estimate the relative risk (RR) of schizophrenia, according to month of birth, gender and other variables, while controlling for father's age and other potential confounders. Other causes of hospitalized psychiatric morbidity (grouped together) were analyzed for comparison. There was a raised incidence of schizophrenia for those who were in the second month of fetal life in June 1967 (RR = 2.3, 1.1-4.7), seen more in females (4.3, 1.7-10.7) than in males (1.2, 0.4-3.8). Results were not explained by secular or seasonal variations, altered birth weight or ...Continue Reading

References

Apr 1, 1978·Archives of General Psychiatry·M O Huttunen, P Niskanen
Dec 1, 1992·Archives of General Psychiatry·E S Susser, S P Lin
May 1, 1969·Paraplegia·E Adler
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·P J MorganeJ R Galler
Aug 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·J van Os, J P Selten
Mar 27, 1999·Schizophrenia Research·J P SeltenR S Kahn
Oct 26, 1999·Development and Psychopathology·J B WatsonX Wang
Feb 15, 2000·The American Journal of Psychiatry·A S BrownE S Susser
Aug 31, 2000·The American Journal of Psychiatry·A ReichenbergM Davidson
Apr 25, 2001·Archives of General Psychiatry·D MalaspinaE S Susser
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Philip Steer
Mar 1, 2005·Human Reproduction·Ralph CatalanoElizabeth Anderson
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·Carolina de Weerth, Jan K Buitelaar
Aug 4, 2005·JAMA : the Journal of the American Medical Association·David St ClairLin He
Sep 20, 2005·Early Human Development·Marie-Paule AustinNicole Reilly
Nov 25, 2005·Schizophrenia Bulletin·Mary Catherine ClarkeMary Cannon
Feb 14, 2006·The Journal of Physiology·Amita KapoorStephen G Matthews
Jun 3, 2006·Schizophrenia Research·David KimhyDolores Malaspina
Jan 5, 2007·Journal of the National Cancer Institute·Susan HarlapRivka Yanetz
Mar 16, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nicole M TalgeVivette Glover
Mar 21, 2007·Physiology & Behavior·Bridget R Mueller, Tracy L Bale
Apr 19, 2007·Paediatric and Perinatal Epidemiology·Susan HarlapYechiel Friedlander
May 4, 2007·Breast Cancer Research and Treatment·M C PerrinS Harlap
May 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Jonathan R Seckl, Megan C Holmes
Jun 7, 2007·Journal of the National Cancer Institute·William H James
Jul 10, 2007·Journal of Autism and Developmental Disorders·Dennis K KinneyErika Gerber
Sep 8, 2007·Physiology & Behavior·María E PallarésRodolfo A Cutrera
Feb 6, 2008·Archives of General Psychiatry·Ali S KhashanPreben Bo Mortensen

❮ Previous
Next ❯

Citations

Nov 23, 2010·Psychopharmacology·Ana-João RodriguesNuno Sousa
Oct 16, 2012·Development and Psychopathology·Catherine MonkFrances A Champagne
May 25, 2010·Current Opinion in Psychiatry·Maria Luisa Figueira, Sílvia Ouakinin
May 26, 2012·Psychiatry and Clinical Neurosciences·Rodrigo Barbachan MansurElisa Brietzke
Apr 26, 2011·Annals of General Psychiatry·Morteza NaserbakhtCassandra L Smith
Jul 9, 2010·Psychoanalytic Review·Arthur A Lynch, Arnold David Richards
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Terrell HollowayJavier González-Maeso
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·José L MorenoJavier González-Maeso
Mar 19, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Min LiWenwen Cheng
Apr 22, 2014·Neuroscience and Biobehavioral Reviews·R Graignic-PhilippeS Tordjman
Jun 1, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giampiero MeliLuigi Cataldi
Oct 13, 2012·International Review of Psychiatry·Oluyomi B EsanOye Gureje
Nov 30, 2013·Biological Psychiatry·Veerle BerginkHemmo A Drexhage
Aug 30, 2012·The Psychiatric Clinics of North America·Mary C ClarkeMary Cannon
Feb 19, 2016·European Journal of Public Health·M DelnordUNKNOWN Euro-Peristat Scientific Committee
Apr 19, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brian J MillerPeter Buckley
Jan 12, 2011·Early Human Development·Saroja KrishnaswamyJemain Abdul Aziz
Oct 20, 2010·Progress in Neurobiology·Alan S Brown
Jul 20, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Carlos BustamanteRodrigo Pascual
Feb 19, 2010·Schizophrenia Research·Brian MillerBrian Kirkpatrick
Oct 28, 2009·Progress in Neurobiology·Urs Meyer, Joram Feldon
Sep 22, 2009·Schizophrenia Research·Bruce I TuretskyPaul J Moberg
Jun 30, 2009·Biochimica Et Biophysica Acta·Tania L RothJoel E Kleinman
Dec 17, 2008·Seminars in Fetal & Neonatal Medicine·Ana Raquel MesquitaOsborne F X Almeida
Jun 30, 2015·Cellular Signalling·Daisuke Ibi, Javier González-Maeso
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephanie M PerezDaniel J Lodge
Aug 25, 2015·International Journal of Public Health·Dell D Saulnier, Kim Brolin
Jan 24, 2013·Bipolar Disorders·Karine KleinhausDolores Malaspina
Sep 25, 2010·Annals of the New York Academy of Sciences·Mary PerrinDolores Malaspina
Mar 19, 2016·Psychopharmacology·Marion LeboyerLaurent Groc
Oct 10, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A M Vaiserman
Apr 3, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nader PerroudFélicien Karege

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