PMID: 9450687Feb 5, 1998Paper

Acute methamphetamine administration increases tyrosine hydroxylase mRNA levels in the rat locus coeruleus

Brain Research. Molecular Brain Research
T ShishidoS Niwa

Abstract

Tyrosine hydroxylase (TH) mRNA levels in the rat substantia nigra (SN), ventral tegmental area (VTA) and locus coeruleus (LC) were measured by in situ hybridization histochemistry 1, 4, 6 and 24 h after a single injection of methamphetamine (MAP, 4 mg/kg, i.p.) or an equivalent volume of saline. TH mRNA levels in LC were transiently increased (130% of control saline group, P < 0.05) at 1 h after MAP injection, and returned to basal levels within 4 h. In contrast, acute MAP administration did not significantly affect TH mRNA levels in SN and VTA. These findings are the first to demonstrate TH mRNA expression in the different responses of catecholaminergic neurons to acute MAP administration.

References

Mar 1, 1979·Brain Research Bulletin·M K SangheraP A Shore
Aug 2, 1990·European Journal of Pharmacology·A L GundlachW J Louis
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E J NestlerR S Duman
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B GrimaJ Mallet
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A BerodJ Mallet
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E J LewisD M Chikaraishi
Dec 1, 1974·European Journal of Pharmacology·M T Price, H C Fibiger
Jan 1, 1993·Neuroreport·A M PersicoG R Uhl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.