Acute methemoglobinemia following attempted suicide by Dapson

Archives of Medical Research
Shahin ShadniaMohammad Abdollahi

Abstract

This report describes the case of an otherwise healthy young adult female, with oral ingestion of 40 unknown tablets. Her clinical course included progressive bluish discoloration of lips and limbs, hemolysis and jaundice. A high PaO2 in the presence of cyanosis and dark blood lead to suspicion of methemoglobinemia. Laboratory results showed methemoglobin level to be 3.8 g/dL (38%). The etiology was traced to dapsone according to patient history; after 3 days it became evident that she had ingested 2 g dapsone in suicidal intent. The therapeutic and diagnostic approach in such patients is discussed. In conclusion, acute methemoglobinemia is an uncommon but potentially treatable disorder.

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Citations

Apr 1, 2008·Indian Journal of Pediatrics·Rajniti PrasadMadhukar Pandey
Dec 20, 2007·American Journal of Therapeutics·Amy ZoselJerrold B Leikin
Oct 26, 2011·Southern Medical Journal·Anna SkoldRobin Klein
Jun 10, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kyung Hye ParkAdam J Singer
Oct 5, 2010·Human & Experimental Toxicology·Shahin ShadniaMohammad Abdollahi
Aug 20, 2011·The Annals of Pharmacotherapy·James A BarclayRami B Ibrahim
Jun 7, 2011·American Journal of Therapeutics·Anna Skold, Robin Klein
Sep 10, 2019·Anesthesiology and Pain Medicine·Farsad ImaniMohamadreza Khajavi
Jul 27, 2021·The American Journal of Forensic Medicine and Pathology·Rosario BarrancoFrancesco Ventura

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