Acute microvascular effects of PAF-acether, as studied by intravital microscopy

European Journal of Pharmacology
J Björk, G Smedegård


Application of PAF-acether (platelet-activating factor) (final concentration 1-20 nM) to the microcirculation of the hamster cheek pouch resulted in dose-dependent vasoconstriction and an increase in macromolecular permeability, as assessed by leakage of intravascular fluorescein-labelled dextran (Mw 150 000). An increase in adhering leukocytes in venules was only seen with 20 nM PAF-acether. Animals made neutropenic by treatment with antineutrophil serum raised in rabbits showed a reduced leakage response to 20 nM PAF-acether, whereas the leakage induced with 5 nM PAF-acether was unaffected. This indicates that the increase in vascular permeability induced by PAF-acether occurs both as a presumably direct effect independent of polymorphonuclear leukocytes (PMNL), and via an indirect PMNL-dependent mechanism. Intravenous administration of PAF-acether (10 micrograms/kg body weight) to hamsters resulted in rapid and transient thrombocytopenia and leukopenia whereas 1 microgram/kg only affected the leukocytes. These potent microvascular effects of PAF-acether support its proposed role as a mediator of allergic and inflammatory reactions.


Jun 28, 1979·Nature·M ChignardJ Benveniste
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S E DahlénB Samuelsson
Sep 1, 1981·The American Journal of Physiology·S R FindlayR N Pinckard
Sep 1, 1981·Inflammation·J T O'FlahertyL R DeChatelet

❮ Previous
Next ❯


Aug 1, 1991·Annals of Neurology·P J LindsbergG Feuerstein
Mar 1, 1985·Inflammation·B GerdinG Smedegøard
Jan 1, 1985·Lung·A B MalikK E Burhop
Apr 29, 1987·European Journal of Pharmacology·M A MartinsB B Vargaftig
Jun 26, 1987·European Journal of Pharmacology·S R O'Donnell, C J Barnett
Sep 1, 1989·European Journal of Pharmacology·D F WoodwardL S Williams
Apr 22, 1992·European Journal of Pharmacology·M G SiroisP Sirois
Jan 1, 1986·Prostaglandins, Leukotrienes, and Medicine·J MehtaW W Nichols
Sep 21, 2000·European Journal of Pharmacology·R E Klabunde, D E Anderson
Sep 26, 1997·Journal of Lipid Mediators and Cell Signalling·D BalsaJ Forn
Jan 1, 1995·Fundamental & Clinical Pharmacology·F KyriacopoulosP Braquet
Dec 1, 1990·British Journal of Pharmacology·M G SiroisP Sirois
Jan 1, 1990·British Journal of Pharmacology·M G HenriquesB B Vargaftig
Feb 1, 1993·British Journal of Pharmacology·J G FilepP Sirois
Jul 1, 1995·Pharmacology & Toxicology·M SakaiT Tanaka
Feb 1, 1985·Acta Physiologica Scandinavica·J BjörkK E Arfors
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·X Li, J W Wilson
Jan 16, 2002·American Journal of Respiratory and Critical Care Medicine·Paolo ParediPeter J Barnes
Jul 1, 1991·The American Review of Respiratory Disease·R C LantzR Burrell
Mar 11, 2006·American Journal of Respiratory and Critical Care Medicine·Bryce N FeltisE Haydn Walters
Jan 1, 1991·Pulmonary Pharmacology·I Macquin-MavierA Harf
Sep 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R D EvansD H Williamson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.