Acute molecular effects of pressure-controlled intermittent coronary sinus occlusion in patients with advanced heart failure

ESC Heart Failure
W MohlPatrick W Serruys

Abstract

Cardiac repair has steered clinical attention and remains an unmet need, because available regenerative therapies lack robust mechanistic evidence. Pressure-controlled intermittent coronary sinus occlusion (PICSO), known to induce angiogenetic and vasoactive molecules as well as to reduce regional ischemia, may activate endogenous regenerative processes in failing myocardium. We aimed to investigate the effects of PICSO in patients with advanced heart failure undergoing cardiac resynchronization therapy. Eight out of 32 patients were treated with PICSO, and the remainder served as controls. After electrode testing including left ventricular leads, PICSO was performed for 20 min. To test immediate molecular responses, in both patient groups, coronary venous blood samples were taken at baseline and after 20 min, the time required for the intervention. Sera were tested for microRNAs and growth factors. To test the ability of up-regulated soluble factors on cell proliferation and expression of transcription factors [e.g. Krüppel-like factor 4 (KLF-4)], sera were co-cultured with human cardiomyocytes and fibroblasts. As compared with controls, significant differential expression (differences between pre-values and post-values in rel...Continue Reading

References

Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Werner MohlKazuhisa Kodama
Sep 28, 2010·Mechanisms of Development·Kota Y MiyasakaToshihiko Ogura
Feb 5, 2014·Journal of the American College of Cardiology·Andrew P AmbrosyMihai Gheorghiade
Jan 27, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Werner MohlFrank Rattay
May 24, 2016·International Journal of Molecular Sciences·Shun Yan, Kai Jiao
Jul 8, 2017·Circulation·Thomas EschenhagenJoseph A Hill
Aug 28, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Werner MohlEmerson C Perin

❮ Previous
Next ❯

Citations

Dec 20, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Werner MohlDavid P Faxon

❮ Previous
Next ❯

Methods Mentioned

BETA
serum collection

Software Mentioned

Miracor
SPSS
RTCA
PICSO

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
W MohlEmerson C Perin
Cardiovascular Revascularization Medicine : Including Molecular Interventions
W MohlFrank Rattay
© 2022 Meta ULC. All rights reserved