Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents

Environmental Toxicology and Pharmacology
Jianzhong WangXingyuan Cao

Abstract

Diaveridine (DVD) is a member of the 2,4-pyrimidinediamine class of dihydrofolate reductase inhibitors. It is used in combination with sulfaquinoxaline as an antiprotozoal agent in animals for the prophylaxis and treatment of coccidiosis and leucocytozoonosis. Herein, we report a complete toxicological safety assessment of DVD for clinical use. The study of toxicity, genetic toxicity (mammalian erythrocyte micronucleus assay, mice sperm abnormality test and in vivo chromosome aberration test of mammalian bone marrow), 90-day sub-chronic toxicity and teratogenicity test were performed. In the acute oral toxicity tests, median lethal dose, LD50, was more than 2378mg/kg body weight in Sprague Dawley rats (1025mg/kg body weight in ICR mice). The testing results for three terms of mutagenicity toxicity (mouse chromosome aberration, erythrocyte micronucleus and sperm abnormality) were all negative at 128-512mg/kg body weight. For 90-day feeding of DVD at the dosage of 10mg/kg body weight in both male and female SD rats, no signs of toxicological effects were detected. Meanwhile, for teratogenicity test in female SD rats at the dosage of 37mg/kg body weight, there were no toxicological signs observed. Thus, our results suggested that ...Continue Reading

References

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Jan 1, 1994·Research in Veterinary Science·P Nielsen, N Gyrd-Hansen
Jul 16, 1999·Mayo Clinic Proceedings·J D Smilack
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Sep 1, 1997·Environmental Toxicology and Pharmacology·T OnoT Ohta
Jul 26, 2015·Regulatory Toxicology and Pharmacology : RTP·Xu WangZonghui Yuan

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Citations

Jan 18, 2017·Journal of Veterinary Pharmacology and Therapeutics·Y-F LiZ-L Zeng

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