Abstract
Reports of acute nonlymphoblastic leukemia occurring after successful treatment of Hodgkin and non-Hodgkin lymphoma (NHL) are appearing with increasing frequency. Two years after completion of LSA2-L2 therapy for stage III, poorly differentiated lymphocytic lymphoma, a 16-year-old boy developed a preleukemic state characterized by a refractory macrocytic anemia with excess blasts, dyshematopoiesis, abnormal cluster:colony ratio on in vitro bone marrow culture, and acquired deficiencies of erythrocyte pyruvate kinase, triose phosphate isomerase, and adenylate kinase. Four months later acute myeloblastic leukemia was evident. The RNA index determined by flow cytofluorometry was increased. Four marker chromosomes were found and involved complex translocation of chromosomes 11 and 17 (t11;l17) in 100% of the cells, and chromosomes 4 (t4q;4) in 10% of the cells. A thorough literature search uncovered four other reports of acute nonlymphoblastic leukemia occurring in children treated for NHL and a total of 58 cases in the adult and pediatric age groups. Over 50% of the patients had AML, were mean over 50 years of age, and were treated with radiotherapy and chemotherapy. It is anticipated that additional cases of second malignancies w...Continue Reading
References
Jan 1, 1978·Acta Haematologica·F CavalliH G Ryssel
Jan 1, 1979·Medicine·D A Casciato, J L Scott
Jul 1, 1978·Cancer·J W VardimanD Variakojis
Jul 1, 1979·Cancer·H MorseA Robinson
Jan 1, 1979·Medical and Pediatric Oncology·R L BaehnerD Hammond
Nov 1, 1979·Pediatric Research·A HagemeijerK Hählen
Jan 1, 1979·Medical and Pediatric Oncology·R E HarrisR L Baehner
Oct 1, 1977·The American Journal of Medicine·B KozinerF P Siegal
Aug 1, 1978·Cancer·J W Linman, G C Bagby
Mar 1, 1979·The New England Journal of Medicine·J G KrikorianH S Kaplan
Sep 1, 1979·Cancer·M H ZarrabiJ M Bennett
Dec 1, 1979·Cancer·C R KjeldsbergH Rappaport
Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·L ZechG Klein
Apr 1, 1975·Radiology·A H RappaportJ R Castro
Jan 1, 1976·American Journal of Hematology·W W ZuelzerM J Ottenbreit
Dec 1, 1976·Cancer·S B Kapadia, S S Kaplan
Dec 1, 1975·British Journal of Haematology·P BoivinA Kahn
Mar 1, 1975·The American Journal of Medicine·F Rosner, H Grünwald
Jan 1, 1975·Medical and Pediatric Oncology·N WollnerM L Murphy
Oct 1, 1974·Archives of Internal Medicine·R T SteigbigelS L Schrier
Nov 1, 1972·Cancer·R B WeissB J Kennedy
Mar 1, 1971·Cancer·S LowenbraunA A Serpick
Nov 30, 1972·The New England Journal of Medicine·J C ArseneauV T DeVita
Nov 1, 1971·Archives of Internal Medicine·J L PothS L Schrier
Apr 1, 1967·Cancer·J Laszlo, H E Grode
Nov 15, 1980·Cancer·A A Sandberg
Jun 1, 1954·Annals of Internal Medicine·E BEUTLER
Feb 1, 1961·Medicine·S A ROSENBERGL F CRAVER
Jul 1, 1960·Annals of Internal Medicine·J H HORNBAKER
Citations
Jul 1, 1982·Indian Journal of Pediatrics·R S Chaganti
Oct 1, 1982·Cancer Genetics and Cytogenetics·A A SandbergS Kakati
Jan 1, 1986·Critical Reviews in Oncology/hematology·M L Bernstein, M J Vekemans
Jan 1, 1988·Pediatric Hematology and Oncology·A OraziG Cattoretti
Jan 17, 2012·Internal Medicine·Hiroaki TanakaChiaki Nakaseko
Jan 1, 1984·Medical and Pediatric Oncology·M P LinkB E Glader
Jan 1, 1986·Scandinavian Journal of Haematology. Supplementum·R Wegelius