Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers

British Journal of Cancer
L RushtonD C Glass

Abstract

High benzene exposure causes acute myeloid leukaemia (AML). Three petroleum case-control studies identified 60 cases (241 matched controls) for AML and 80 cases (345 matched controls) for chronic lymphoid leukaemia (CLL). Cases were classified and scored regarding uncertainty by two haematologists using available diagnostic information. Blinded quantitative benzene exposure assessment used work histories and exposure measurements adjusted for era-specific circumstances. Statistical analyses included conditional logistic regression and penalised smoothing splines. Benzene exposures were much lower than previous studies. Categorical analyses showed increased ORs for AML with several exposure metrics, although patterns were unclear; neither continuous exposure metrics nor spline analyses gave increased risks. ORs were highest in terminal workers, particularly for Tanker Drivers. No relationship was found between benzene exposure and risk of CLL, although the Australian study showed increased risks in refinery workers. Overall, this study does not persuasively demonstrate a risk between benzene and AML. A previously reported strong relationship between myelodysplastic syndrome (MDS) (potentially previously reported as AML) at our s...Continue Reading

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Citations

Jul 28, 2015·Expert Review of Anticancer Therapy·Marc De BraekeleerNathalie Douet-Guilbert
Apr 15, 2015·International Journal of Environmental Research and Public Health·Raeesa MoollaJasper Knight
Apr 14, 2015·British Journal of Cancer·J S StenehjemT K Grimsrud
Sep 8, 2016·International Journal of Cancer. Journal International Du Cancer·Jenny N PoynterErica Warlick
Jun 27, 2017·Journal of Occupational and Environmental Hygiene·D C GlassL Rushton
Mar 30, 2019·Risk Analysis : an Official Publication of the Society for Risk Analysis·Harvey CheckowayKenneth A Mundt
May 16, 2018·Annals of Occupational and Environmental Medicine·Jin-Ha YoonYeon-Soon Ahn
Nov 12, 2019·International Journal of Environmental Health Research·Pauline McLooneDinara Kenessary
Dec 16, 2017·Critical Reviews in Toxicology·Sherilyn A Gross, Dennis J Paustenbach
Jul 15, 2015·International Journal of Epidemiology·Deborah C GlassMalcolm R Sim
May 21, 2020·Environmental Health : a Global Access Science Source·Calvin JephcoteAlice Mah
Jan 12, 2021·Toxicology Letters·Colin M NorthStephen D Williams
May 1, 2021·International Journal of Environmental Research and Public Health·Felix M OnyijeAnn Olsson

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Methods Mentioned

BETA
MDS

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