Abstract
Acute myeloid leukemia (AML) is well-recognized as one of the most important second malignancies. We report the occurrence of secondary AML (sAML) in our institution. From September 1987 to August 1996 we have observed sAML in 9 patients (median age 4 years), 5 of them previously treated for hematologic malignancies (group I): acute lymphoblastic leukemia (n = 2), AML (n = 1), non-Hodgkin lymphoma (n = 1). Hodgkin disease (n = 1), and 4 of these 9 patients treated for solid tumors (group II): neuroblastoma (n = 1), retinoblastoma (n = 1), Wilms tumor (n = 1), and central nervous system germinoma (n = 1). All the patients had topoisomerase II inhibitors as part of treatment of their first malignancy, but only 5 patients received epipodophyllotoxins. Alkylating agents were part of primary therapy in 8 of 9 patients. The latency period for the development sAML was 26.5 (range = 2-55) months. The morphologic FAB features of sAML were M5 (n = 5), M4 (n = 3), and M2 (n = 1). Cytogenetic studies showed r11q23 in 3 patients, all of them with prior hematological malignancies. Initial therapy for sAML in all cases was chemotherapy (including cytarabine in combination with idarubicin and etoposide or doxorubicin or mitoxantrone). Three pa...Continue Reading
References
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S P HungerM P Link
Mar 14, 1992·Journal of the National Cancer Institute·F X Mahaney
Dec 1, 1991·Environmental Health Perspectives·W A Anwar
Dec 12, 1991·The New England Journal of Medicine·C H PuiJ T Sandlund
Feb 1, 1990·British Journal of Haematology·T De WitteJ Gmür
Apr 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A T MeadowsS G Sallan
Oct 1, 1985·Annals of Internal Medicine·J M BennettC Sultan
Nov 1, 1984·Cancer Genetics and Cytogenetics·D L WilliamsW Lemonds
Sep 1, 1995·Medical and Pediatric Oncology·R K MulhernE I Thompson
Apr 1, 1995·Leukemia Research·J M Bennett
Sep 1, 1993·Leukemia & Lymphoma·M EllisM Lishner
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S B Murphy
Nov 1, 1996·Leukemia Research·F Sackmann-MurielJ Rossi
Mar 1, 1997·Cancer·E S SandlerG R Buchanan
Citations
Aug 10, 1999·Leukemia & Lymphoma·M S FeliceF Sackmann-Muriel
Jul 7, 2007·Ophthalmology·Dan S GombosChristopher Bing On Yu
May 4, 2004·Ophthalmology·David H Abramson, Amy C Schefler
Sep 26, 2017·Journal of Pediatric Hematology/oncology·María S FelicePedro A Zubizarreta
Apr 10, 2002·International Journal of Hematology·Shinsaku ImashukuShigeyoshi Hibi
Jan 19, 2007·Journal of Pediatric Hematology/oncology·Bina Sharine MenonLin Hai Peng
Sep 7, 2007·Journal of Pediatric Hematology/oncology·Michael WeintraubJacob Pèer
Mar 17, 2018·Bone Marrow Transplantation·Adam GassasPersis Amrolia
Apr 2, 1999·Medical and Pediatric Oncology·L F Lopes, B de Camargo