Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report

Medicine
Wei-Wei MaBing-Rong Zhou

Abstract

Atopic dermatitis (AD) is a chronic recurrent dermatitis with profound itching, which could be the first manifestation of acute myeloid leukemia (AML). A 53-year-old Chinese man suffered a 6-month history of systemic symmetrical dermatitis, accompanied with profound itching. The patient was diagnosed as "eczema" in several hospitals, and the effects of antihistamine and topical steroid creams were poor. Nocturnal sleep was seriously affected by aggravating pruritus. Laboratorial examination was compatible with AML-M4. AML-M4 with AD as first manifestation. IA regimen (ayninen and cytarabine) were used in induction chemotherapy. However, the patient did not achieve complete remission, and although his rash had improved, he still experienced severely general body itching. On the seventh day of chemotherapy, the patient entered the period of granulocyte deficiency with infection. The patient died due to septic shock after chemotherapy. The case strengthens the awareness of AML with AD as first manifestation and raises oncological vigilance in patients with AD refractory.

References

Jul 21, 2009·Journal of Cutaneous Pathology·Crystal G ThomasWilma F Bergfeld
Mar 17, 2010·American Journal of Epidemiology·Amy M LinaberyJulie A Ross
Nov 26, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar WagnerMichael Max Sachse
Sep 26, 2012·Journal of Pediatric Hematology/oncology·Nazanin K MajdRamzi Abdulrahman
Dec 19, 2012·Indian Journal of Dermatology·Angoori G Rao, Indira Danturty
May 31, 2014·Journal of Cutaneous Pathology·Chutika SrisuttiyakornRossitza Lazova
May 15, 2016·Seminars in Oncology·Michael R GrunwaldJonathan M Gerber
Jul 9, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret R O'DonnellNdiya Ogba

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biopsy

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