Acute myeloid leukemia with minimal differentiation. A multiple parameter study

American Journal of Clinical Pathology
P L CohenC A Hanson

Abstract

Acute myeloid leukemia with minimal differentiation (AML-M0) is a recently described entity, and few large studies are available to characterize its clinical and pathologic features. We reviewed blood and bone marrow morphology, cytochemistry, immunophenotyping, and cytogenetics, as well as the clinical findings, of 17 patients with AML-M0. Most patients were male, with a median age of 62 years. Minimal background myelodysplastic features were identified in only 5 of 15 patients. Cytochemical stains for myeloperoxidase and alpha-naphthyl butyrate esterase were negative in the leukemic blasts of all specimens. Positivity for one or both myeloid-associated antigens, CD13 and CD33, was seen in all patients. Both CD34 and HLA-DR were positive in all tested cases. Lymphoid-associated antigens were identified in seven patients; these antigens were typically dim or weak in intensity. Terminal deoxynucleotidyltransferase positivity was seen in 14 of 14 tested patients; monoclonal anti-myeloperoxidase reactivity was seen in the blasts of 2 patients. Abnormal clonal karyotypes were found in 6 of 14 patients. Abnormalities of chromosomes 7 and 13 were the most common findings, most frequently manifested by monosomy 7 and trisomy 13. The m...Continue Reading

Citations

Dec 28, 1999·Leukemia & Lymphoma·S FujisawaY Ishigatsubo
Jul 5, 2003·International Journal of Hematology·Ritsuro SuzukiShigeo Nakamura
May 9, 2000·Memórias do Instituto Oswaldo Cruz·J C Voltarelli
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Abolghasem AllahyariMasoud Sadeghi
May 8, 2000·Medical and Pediatric Oncology·M KuzmanovicV Bunjevacki
Aug 14, 2001·Critical Reviews in Oncology/hematology·A PintoF Ferrara
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Randall J OlsenAamir Ehsan

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.