Acute myeloneuropathy: An uncommon presentation of Sjögren's syndrome

Annals of Indian Academy of Neurology
Rajesh VermaVinod Mehta

Abstract

Sjögren's syndrome is associated with central and peripheral nervous system involvement. The peripheral neuropathy is usually a sensory predominant neuropathy or a cranial neuropathy. Myelopathy is usually of focal, subacute, chronic or relapsing type. Acute myeloneuropathy as the predominant manifestation has not been described in the literature. We describe a middle aged woman who presented with an acute onset motor quadriparesis and bladder dysfunction. She had dryness of eyes and mouth for 8 months. Nerve conduction studies revealed motor axonal neuropathy and magnetic resonance imaging of spinal cord showed T2 hyperintensities involving entire cord. Mild perineural fibrosis, focal foamy changes in endoneurium and lymphocytic infiltration were seen in sural nerve biopsy specimen. Patient improved clinically after intravenous methylprednisolone therapy.

References

May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Sep 3, 2004·Medicine·Sophie DelalandePierre-Yves Hatron
Jul 29, 2005·Brain : a Journal of Neurology·Keiko MoriGen Sobue
Oct 27, 2010·Muscle & Nerve·Amer AwadBashar Katirji
Aug 3, 2011·Annals of Indian Academy of Neurology·Ravi YadavD Nagraja

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Citations

Mar 25, 2016·Annals of Indian Academy of Neurology·Rajesh VermaSuresh Babu
Aug 21, 2015·Rinshō shinkeigaku = Clinical neurology·Atsushi YamamotoMasatoshi Kadoya
Jun 14, 2016·Annals of Indian Academy of Neurology·Ravindra Kumar GargNeeraj Kumar

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
electrophoresis
biopsy

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