PMID: 9170024Apr 1, 1997Paper

Acute myopathy induced by colchicine in a cyclosporine-treated renal transplant recipient--a case report and review of the literature

Journal of Korean Medical Science
B I LeeB K Bang

Abstract

We report a case of colchicine-induced myopathy related to short-term, customary administration of colchicine. A 49-year-old male was admitted because of muscle weakness and myalgia that had developed 10 days previously. He had received renal transplantation 5 years previously and took cyclosporine as an immunosuppressant. Two weeks before admission, gout was developed and he took colchicine (1.2 mg b.i.d) by himself for three days. Colchicine-induced myopathy was clinically suspected, and colchicine intake was stopped immediately. After that, clinical symptoms gradually improved and serum muscle enzyme returned to normal. In this case, mild renal dysfunction and drug interaction between cyclosporine and colchicine wee suggested to be the precipitating factors of colchicine-induced myopathy.

Citations

Jul 28, 2019·Medicine·Mingjie FuAnwei Lu
Nov 24, 1999·Muscle & Nerve·M Breil, P Chariot
Dec 9, 2004·Pharmacotherapy·Kerry Wilbur, Mark Makowsky
Jul 9, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Giorgio EleftheriouRoberta Sebastiano
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·David M Clive
Jul 23, 2021·BMJ Case Reports·Mohammad AbudalouAli Al Sbihi

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