Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice

Critical Care : the Official Journal of the Critical Care Forum
Shouri LahiriMaya Koronyo-Hamaoui

Abstract

Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding is particularly evident among older individuals who have pre-existing cognitive impairment, most commonly characterized by varying degrees of cerebral amyloid-β accumulation, neuroinflammation, and blood-brain barrier dysfunction. We sought to test the hypothesis that short-term mechanical ventilation contributes to the neuropathology of cognitive impairment by (i) increasing cerebral amyloid-β accumulation in mice with pre-existing Alzheimer's disease pathology, (ii) increasing neurologic and systemic inflammation in wild-type mice and mice with pre-existing Alzheimer's disease pathology, and (iii) increasing hippocampal blood-brain barrier permeability in wild-type mice and mice with pre-existing Alzheimer's disease pathology. We subjected double transgenic Alzheimer's disease (APP/PSEN1) and wild-type mice to mechanical ventilation for 4 h and compared to non-mechanically ventilated Alzheimer's disease model and wild-type mice. Cerebral soluble/insoluble amyloid-β1-40/amyloid-β1-42 and neurological and systemic markers of inflammation were quantified. Hippocampal blood-brain barrier permeability was quantified using a no...Continue Reading

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Citations

Nov 14, 2019·Critical Care : the Official Journal of the Critical Care Forum·Cina SasannejadShouri Lahiri
Feb 2, 2020·Critical Care : the Official Journal of the Critical Care Forum·Giovanni GiordanoFederico Bilotta
Aug 8, 2019·Critical Care : the Official Journal of the Critical Care Forum·Federico BilottaFrancesco Pugliese
Nov 25, 2020·Acta Neuropathologica Communications·Haoshen ShiMaya Koronyo-Hamaoui
Mar 7, 2021·Brain Sciences·Marcello CiaccioLuisa Agnello
Aug 4, 2021·British Journal of Anaesthesia·Guillermo M AlbaicetaLluis Blanch
May 21, 2021·American Journal of Respiratory Cell and Molecular Biology·Nicklaus A SparrowShouri Lahiri
Dec 4, 2021·Intensive Care Medicine Experimental·Paula Martín-VicenteLaura Amado-Rodríguez

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Methods Mentioned

BETA
transgenic
enzyme-linked immunosorbent assay
Protein
ELISA
Cytomation
confocal microscopy
sedation
bronchoalveolar lavage

Software Mentioned

ImageJ
AxioVision
GraphPad Prism

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