PMID: 8962593May 1, 1996Paper

Acute neurotoxicity of meperidine in an infant

Pediatric Neurology
R P SanetoB H Cohen

Abstract

We report a 6-week-old boy with meperidine neurotoxicity. What distinguished our patient from those previously reported was his minimal exposure to therapeutic doses of meperidine in the setting of normal renal function, and no history of sickle cell anemia, cancer, hepatitis, or cirrhosis. In addition, our patient had no abnormal changes in the electroencephalogram during the event. After only 2 doses of meperidine, he exhibited acute orofacial dyskinesias consisting of tongue thrusting, lip pursing, and facial grimacing combined with prominent flexion of the arms and stiffening of his legs. However, a normal sucking response remained. His symptoms resolved over the next 36 hours and did not respond to naloxone. We believe that this unique presentation of meperidine-induced neurotoxicity may be due to changes in the basal ganglia resulting from perinatal hypoxemia.

References

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Citations

Feb 21, 2004·The Journal of Pain : Official Journal of the American Pain Society·Sebastiano Mercadante, Edoardo Arcuri
May 24, 2005·Journal of Pain and Symptom Management·Jörn Lötsch
Jan 10, 2002·American Journal of Therapeutics·Kenneth S LattaRobert L Barkin
Dec 19, 2012·Journal of Clinical Anesthesia·Hou-Chuan LaiGo-Shine Huang
Oct 17, 2002·Clinics in Perinatology·Anna Taddio
Jul 2, 2008·Mitochondrion·Russell P SanetoDennis W W Shaw
Apr 15, 2014·Korean journal of anesthesiology·Ji Yeon Lee, Youn Yi Jo
Apr 23, 2019·European Journal of Drug Metabolism and Pharmacokinetics·James C ThigpenSam Harirforoosh
Apr 6, 2012·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Kim W Benner, Spencer H Durham

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