Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study

Pharmacology, Biochemistry, and Behavior
C EngelandVerner J Knott

Abstract

The auditory mismatch negativity (MMN) event-related brain potential (ERP) reflects the storage of information in acoustic sensory memory. Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and placebo. MMNs were recorded with 1- and 3-s interstimulus intervals (ISIs) during pre- and post-placebo/nicotine administration. Amplitudes decreased from pre- to post-placebo recordings in nontreated patients but remained stable in THA-treated patients. Comparison of pre- and post-nicotine MMNs found amplitude increases with nicotine in nontreated but not in THA-treated patients. MMN latencies were shortened by nicotine in both treatment groups. These exploratory findings suggest that nicotine-improved strength of acoustic sensory memory traces and speed of acoustic sensory discrimination in AD are differentially affected by chronic tacrine treatment.

References

Nov 3, 1977·Nursing Mirror·S Powter
Jul 1, 1978·Acta Psychologica·R NäätänenS Mäntysalo
May 1, 1976·British Medical Journal·M A RussellP V Cole
Jan 1, 1992·Psychopharmacology·E D Levin
Oct 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T W Picton
May 1, 1990·Electroencephalography and Clinical Neurophysiology·J PolichF E Bloom
Jan 1, 1991·Psychopharmacology·S C Provost, R Woodward
Feb 1, 1990·Pharmacopsychiatry·J DelacourH Kleinlogel
Jun 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·B SahakianD Warburton
Jan 1, 1988·Psychopharmacology·P A NewhouseD L Murphy
Mar 29, 1988·European Journal of Pharmacology·L RomanelliA Nordberg
Jan 1, 1985·Addictive Behaviors·J A EdwardsA Gale
Jan 1, 1983·Pharmacology & Therapeutics·K Wesnes, D M Warburton
Mar 1, 1984·Psychophysiology·A MaglieroE Donchin
Jul 30, 1982·Science·R T BartusA S Lippa
Nov 1, 1995·Electroencephalography and Clinical Neurophysiology·E PekkonenR Näätänen
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·I P JääskeläinenP Sillanaukee
Nov 1, 1993·Electroencephalography and Clinical Neurophysiology·E PekkonenJ Karhu
Aug 1, 1994·Molecular Neurobiology·E Giacobini
Jan 1, 1995·Alzheimer Disease and Associated Disorders·A D Lawrence, B J Sahakian
Oct 1, 1995·Biological Psychology·J Polich, A Kok
Apr 1, 1996·Experimental Aging Research·E PekkonenR Näätänen
Feb 1, 1996·Psychopharmacology·M E HoulihanJ H Robinson
Sep 1, 1997·Biological Psychiatry·V A KazmerskiW Ritter
Oct 29, 1997·Psychopharmacology·P RiekkinenP Riekkine
Mar 21, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J Polich
Nov 6, 1998·Journal of Cognitive Neuroscience·C EsceraR Näätänen

❮ Previous
Next ❯

Citations

Dec 24, 2002·Human Psychopharmacology
Jun 19, 2012·Psychopharmacology·Naofumi OtsuruRyusuke Kakigi
Jun 1, 2005·NeuroImage·Eero PekkonenJyrki Ahveninen
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Rie InamiHeii Arai
May 14, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Laura F MartinMichael A Kisley
Nov 27, 2007·Neuropsychobiology·Rie InamiHeii Arai
Dec 8, 2004·Journal of Psychopharmacology·Kristi A SaccoTony P George
Nov 6, 2007·Pharmacogenomics·Jill C Mwenifumbo, Rachel F Tyndale
Aug 28, 2014·Current Psychiatry Reports·Jennifer N Vega, Paul A Newhouse
Jul 9, 2008·Journal of Neural Transmission·Elisabeth GlassWaldemar von Suchodoletz
Apr 18, 2014·PloS One·Christian KärgelBernhard W Müller
Apr 22, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Verner J KnottCrystal Villeneuve
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Allison C Hoffman, Sarah E Evans
Nov 27, 2009·Journal of Psychopharmacology·Verner KnottCrystal Villeneuve
Feb 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marta I GarridoKarl J Friston
Sep 4, 2010·Journal of Clinical Psychopharmacology·Louise DuludeVerner J Knott
Jan 27, 2015·Journal of Neural Transmission·Danielle Impey, Verner Knott
Jul 25, 2019·Journal of Cancer Survivorship : Research and Practice·Jennifer N VegaPaul A Newhouse
May 2, 2018·Neurotoxicity Research·Aleksander A AleksandrovRaul R Gainetdinov
Jul 10, 2021·Brain : a Journal of Neurology·Ece KocagoncuJames B Rowe
Dec 16, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R NäätänenC Ponton
Feb 18, 2021·Current Alzheimer Research·Eunchan NaKi W Kim

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