Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain

Environmental Research
Wei YanNan Sang

Abstract

Recent epidemiological literatures imply that NO2 is a potential risk factor of neurological disorders. Whereas, the pathogenesis of various neurological diseases has been confirmed correlate to mitochondrial dysfunction, and mitochondria play the crucial roles in energy metabolism, free radicals production and apoptosis triggering in response to neuronal injury. Therefore, to clarify the possible mechanisms for NO2-induced neurotoxicity, in the present study, we investigated the possible effects of acute NO2 inhalation (5, 10 and 20mg/m(3) with 5h/day for 7 days) on energy metabolism and biogenesis in rat cortex, mainly including mitochondrial ultrastructure, mitochondrial membrane potential, cytochrome c oxidase activity, cytochrome c oxidase (CO) and ATP synthase subunits, ATP content, and transcription factors. The results showed that NO2 exposure induced mitochondrial morphological changes in rat cortex, and the alteration was coupled with the abnormality of mitochondrial energy metabolism, including decreased respiratory complexes, reduced ATP production and increased production of ROS. Also, increased ROS in turn caused mitochondrial membrane damage, energy production defect and mitochondrial biogenesis inhibition. It su...Continue Reading

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Citations

Apr 6, 2017·Expert Reviews in Molecular Medicine·Sasan AndalibAlbert Gjedde
Apr 25, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jian V HuangC Mary Schooling
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Pengfei Fu, Ken Kin Lam Yung
Sep 1, 2016·Environmental Health : a Global Access Science Source·Guo-Zhen LinChun-Quan Ou
Jan 8, 2019·Particle and Fibre Toxicology·Keith Morris-SchafferDeborah A Cory-Slechta
Mar 19, 2019·Basic & Clinical Pharmacology & Toxicology·Jordi Sunyer, Payam Dadvand
Oct 7, 2020·Annals of the New York Academy of Sciences·Brittany WoodbyGiuseppe Valacchi
Dec 10, 2020·Immunity & Ageing : I & a·Alistair V W NunnJimmy D Bell
Jan 8, 2021·International Journal of Environmental Research and Public Health·Meng-Chieh ChenChao-Hung Kuo
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaila Musa ChiromaMohamad Aris Mohd Moklas

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