Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro

British Journal of Pharmacology
C FürnsinnW Waldhäusl

Abstract

1. The direct short-term effects of troglitazone on parameters of glucose metabolism were investigated in rat soleus muscle strips. 2. In muscle strips from Sprague-Dawley rats, troglitazone (3.25 micromol l(-1)) increased basal and insulin-stimulated glucose transport by 24% and 41%, respectively (P<0.01 each). 3. In the presence of 5 nmol l(-1) insulin, stimulation of glucose transport by 3.25 micromol l(-1) troglitazone was accompanied by a 36% decrease in glycogen synthesis, while glycolysis was increased (112% increase in lactate production) suggesting a catabolic response of intracellular glucose handling. 4. Whereas insulin retained its stimulant effect on [3H]-2-deoxy-glucose transport in hypoxia-stimulated muscle (by 44%; c.p.m. mg(-1) h(-1): 852+/-77 vs 1229+/-75, P<0.01), 3.25 micromol l(-1) troglitazone failed to increase glucose transport under hypoxic conditions (789+/-40 vs 815+/-28, NS) suggesting that hypoxia and troglitazone address a similar, non-insulin-like mechanism. 5. No differences between troglitazone and hypoxia were identified in respective interactions with insulin. 6. Troglitazone acutely stimulated muscle glucose metabolism in a hypoxia/contraction-like manner, but it remains to be elucidated whet...Continue Reading

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Citations

Mar 18, 2003·Life Sciences·David A Van DykeLarry L Louters
Mar 2, 1999·British Journal of Pharmacology·K PreiningerM Roden
Sep 13, 2001·Clinical and Experimental Pharmacology & Physiology·J YoshiokaT Nishimura
May 1, 2004·Journal of Medicinal Food·Sun-ju Yi, Byung H Jhun
Jul 28, 2001·Diabetes Technology & Therapeutics·B J Goldstein
Apr 23, 2002·Pharmacogenomics·Carsten OttoBurkhard Göke
Oct 1, 2008·Expert Opinion on Drug Discovery·Apiradee Sriwijitkamol, Nicolas Musi
May 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·C Day
Feb 9, 2006·American Journal of Physiology. Endocrinology and Metabolism·Nathan K LeBrasseurEva Tomas
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Greg CoatesTomas Welbourne
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Robert RouthTomas Welbourne
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tomas WelbourneHarold Battarbee
Oct 10, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Seung-Hwan MoonKyung-Han Lee

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