Acute occlusive large vessel disease leading to fatal stroke in a patient with systemic lupus erythematosus: arteritis or atherosclerosis?

Arthritis and Rheumatism
Katrin L ConenBarbara C Biedermann

Abstract

A woman with a history of systemic lupus erythematosus presented with extensive bilateral strokes due to acute inflammatory, occlusive large vessel disease affecting several aortic branches including the carotid, subclavian, renal, and iliac arteries. We quantitatively characterized the arterial inflammation in this patient and compared it with the inflammatory infiltrates from 22 patients with conventional atherosclerosis. Profound histomorphologic differences from conventional atherosclerosis (predominance of CD8-positive lymphocytes, relative absence of macrophages, no ectopic neovascularization, no signs of plaque hemorrhage, concentric instead of eccentrical stenosis) suggest that this patient's accelerated arteriopathy was precipitated by pathogenic events other than conventional atherosclerosis.

References

Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Sep 1, 1991·Southern Medical Journal·S M HarmonK W Min
Apr 18, 2000·Rheumatic Diseases Clinics of North America·F AndradeA Rosen
Dec 20, 2002·Nature·Peter Libby
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Karen S MoultonJudah Folkman
Aug 29, 2003·The New England Journal of Medicine·Howard J EisenUNKNOWN RAD B253 Study Group
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Dec 19, 2003·The New England Journal of Medicine·Mary J RomanJane E Salmon
Sep 8, 2004·Autoimmunity Reviews·Andrea T BorchersM Eric Gershwin

❮ Previous
Next ❯

Citations

Mar 13, 2012·Neurology India·Young Seo KimSeung-Hyun Kim
Aug 19, 2008·Human Pathology·Jan GewaltigBarbara C Biedermann
May 28, 2008·Best Practice & Research. Clinical Haematology·Barbara C Biedermann
Aug 11, 2017·Clinical Physiology and Functional Imaging·H ZachrissonP Eriksson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.