Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder

Glia
Jessie NewvilleLee Anna Cunningham

Abstract

Alcohol exposure during central nervous system (CNS) development can lead to fetal alcohol spectrum disorder (FASD). Human imaging studies have revealed significant white matter (WM) abnormalities linked to cognitive impairment in children with FASD; however, the underlying mechanisms remain unknown. Here, we evaluated both the acute and long-term impacts of alcohol exposure on oligodendrocyte number and WM integrity in a third trimester-equivalent mouse model of FASD, in which mouse pups were exposed to alcohol during the first 2 weeks of postnatal development. Our results demonstrate a 58% decrease in the number of mature oligodendrocytes (OLs) and a 75% decrease in the number of proliferating oligodendrocyte progenitor cells (OPCs) within the corpus callosum of alcohol-exposed mice at postnatal day 16 (P16). Interestingly, neither mature OLs nor OPCs derived from the postnatal subventricular zone (SVZ) were numerically affected by alcohol exposure, indicating heterogeneity in susceptibility based on OL ontogenetic origin. Although mature OL and proliferating OPC numbers recovered by postnatal day 50 (P50), abnormalities in myelin protein expression and microstructure within the corpus callosum of alcohol-exposed subjects per...Continue Reading

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Citations

Nov 25, 2017·Neural Regeneration Research·Jessie NewvilleLee Anna Cunningham
Apr 23, 2019·Alcoholism, Clinical and Experimental Research·Alexander M TsengRajesh C Miranda
May 17, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James Rice, Chen Gu
Nov 21, 2019·The Journal of Obstetrics and Gynaecology Research·Takashi HirayamaKatsuhiko Nishimori
Apr 5, 2018·Frontiers in Molecular Neuroscience·José J Miguel-Hidalgo
Nov 16, 2020·Neurobiology of Disease·Nune DarbinianLaura Goetzl
Aug 13, 2021·Neural Regeneration Research·Nune Darbinian, Michael E Selzer
Nov 27, 2021·Alcoholism, Clinical and Experimental Research·Jessie NewvilleLee Anna Cunningham

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