Acute oral toxicity of nickel compounds

Regulatory Toxicology and Pharmacology : RTP
Rayetta G HendersonHudson K Bates

Abstract

Acute oral toxicity studies were conducted on samples of nine unique nickel compounds and two complex materials to comply with the data and classification requirements of the new Registration, Evaluation, and Authorization of Chemicals Regulation (REACH) in Europe. The samples tested in this study confirmed the overall low oral toxicity of nickel substances and demonstrated a wide range of LD(50) values extending from 310 to >11,000 mg/kg. This variation highlights the differences in toxicological properties between various forms of nickel and underscores the importance of Ni(II) ion bioavailability in determining toxicity. The relative acute oral toxicity of the various nickel substances was found to be: nickel fluoride, nickel sulfate, nickel chloride, nickel acetate > nickel sulfamate > nickel hydroxycarbonate > nickel dihydroxide > nickel subsulfide, nickel oxides, nickel ash, nickel mattes. Based on these data, four nickel compounds would receive a Category 4 acute toxicity classification according to the European Regulation on Classification, Labelling and Packaging of Chemical Substances and Mixtures (CLP), while the rest of the nickel substances tested fit the criterion for no classification. These data also provided th...Continue Reading

References

Feb 1, 1991·Regulatory Toxicology and Pharmacology : RTP·V J Zatka
Nov 30, 2006·International Journal of Toxicology·Shayne C GadHeide Robbe
Mar 1, 2012·Regulatory Toxicology and Pharmacology : RTP·Rayetta G HendersonAdriana R Oller

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Citations

Dec 26, 2015·International Journal of Molecular Sciences·Hongrui GuoBangyuan Wu
Mar 1, 2012·Regulatory Toxicology and Pharmacology : RTP·Rayetta G HendersonAdriana R Oller
Jun 10, 2016·Bulletin of Environmental Contamination and Toxicology·Dean MeyerPhillip L Williams
Sep 16, 2016·Ecotoxicology and Environmental Safety·Renata Świergosz-Kowalewska, Anita Tokarz
Sep 16, 2016·Environmental Geochemistry and Health·Vojtěch EttlerCécile Quantin
Aug 18, 2016·Angewandte Chemie·Ksenia S Egorova, Valentine P Ananikov
May 3, 2019·Toxicology Mechanisms and Methods·Xiaotian ZhangChanghao Liang
Feb 28, 2018·Child Development·Danielle M Dalimonte-Merckling, Holly E Brophy-Herb
Aug 24, 2019·Development and Psychopathology·Leslie D LeveDavid Reiss
Jan 25, 2020·International Journal of Environmental Research and Public Health·Giuseppe GenchiAlessia Catalano
Sep 25, 2019·International Journal of Molecular Sciences·Hongrui GuoLing Zhao

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