Acute otorrhea in children with tympanostomy tubes: prevalence of bacteria and viruses in the post-pneumococcal conjugate vaccine era

The Pediatric Infectious Disease Journal
Thijs M A van DongenAnne G M Schilder

Abstract

Acute tympanostomy-tube otorrhea is a common sequela in children with tympanostomy tubes. Acute tympanostomy-tube otorrhea is generally a symptom of an acute middle ear infection, whereby middle ear fluid drains through the tube. The widespread use of pneumococcal conjugate vaccination (PCV) has changed the bacterial prevalence in the upper respiratory tract of children, but its impact on bacterial and viral pathogens causing acute tympanostomy-tube otorrhea is yet unknown. This study was performed in the post-PCV7 era parallel to a randomized clinical trial of the clinical and cost-effectiveness of ototopical and systemic antibiotics and initial observation in 230 children aged 1 to 10 years with untreated, uncomplicated acute tympanostomy-tube otorrhea. Otorrhea and nasopharyngeal samples were collected at baseline (before treatment) and at 2 weeks (after treatment). Conventional bacterial culture was performed followed by antimicrobial-resistance assessment. Viruses were identified by polymerase chain reaction. At baseline, Haemophilus influenzae (41%), Staphylococcus aureus (40%) and Pseudomonas aeruginosa (18%) were the most prevalent bacteria in otorrhea, followed by Streptococcus pneumoniae (7%) and Moraxella catarrhalis...Continue Reading

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Citations

Nov 7, 2015·PloS One·Monica T Y WongElisabeth H Schölvinck
Apr 5, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Stephen J BarenkampW Edward Swords
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Sep 9, 2016·Nature Reviews. Disease Primers·Anne G M SchilderRoderick P Venekamp
Mar 25, 2020·Ear, Nose, & Throat Journal·Tal MaromSharon Ovnat Tamir
Dec 5, 2019·Therapeutic Advances in Infectious Disease·Tal MaromJacob Pitaro
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Jan 10, 2021·Antibiotics·Elena Lia SpoialăCristina Gavrilovici
Jun 24, 2019·International Journal of Pediatric Otorhinolaryngology·Amir EmamiMohammad Motamedifar
Jun 27, 2021·American Journal of Otolaryngology·Jennifer L McCoyJoseph E Dohar
Jun 25, 2021·The Pediatric Infectious Disease Journal·Saskia HullegieRoger A M J Damoiseaux

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