Acute overdosage with benzodiazepine derivatives

Clinical Pharmacology and Therapeutics
D J GreenblattR I Shader


A total of 773 admissions to Massachusetts General Hospital between 1962 and 1975 were due to acute overdosage with one or more psychotropic drugs. Benzodiazepine overdosage, particularly with diazepam, increased relative to other psychotropic drugs over the years. Only 12 admissions were due to benzodiazepine overdosage alone, and none of these patients were seriously ill or had significant complications. Multiple drugs were ingested in the other 87 cases, and the frequency and severity of complications among these individuals depended upon the type and quantity of other nonbenzodiazepines taken. For example, 21 of 31 patients who ingested benzodiazepines together with barbiturates experienced severe central nervous system (CNS) depression, and 14 of 31 required assisted ventilation. However, the frequency of such complications was nearly identical in a group of patients who ingested barbiturates alone. This report and a review of the literature suggest that serious intoxication following overdosage with a benzodiazepine derivative alone is unusual. Ingestion of benzodiazepines together with other drugs appears to be considerably more common than benzodiazepine overdosage alone as a cause of intoxication. The severity of intox...Continue Reading


Sep 1, 1991·Human & Experimental Toxicology·G Milicević, H Prpić
Sep 1, 1991·Journal of Clinical Pharmacology·R I ShaderM B Balter
Jan 1, 1981·British Journal of Clinical Pharmacology·K Rickels
Jun 23, 2004·British Journal of Clinical Pharmacology·Geoffrey K IsbisterIan M Whyte
Nov 1, 1979·Journal of Clinical Pharmacology·D J GreenblattR I Shader
Jan 1, 1991·Intensive Care Medicine·P F Mannaioni
Sep 1, 1977·Agents and Actions·W E Haefely
Mar 1, 1982·Acta Pharmacologica Et Toxicologica·L Aaltonen, M Scheinin
Oct 1, 1996·Journal of Clinical Psychopharmacology·U E BustoA Gacitúa
Jun 25, 2004·Journal of Toxicology. Clinical Toxicology·Donna L Seger
Mar 21, 2012·Anesthesia Progress·Daniel E Becker
Jan 18, 2014·Journal of Pharmacy Practice·Michael JannGaylord Lopez
Dec 1, 1977·Clinical Toxicology·M D AllenB J Noel
Mar 1, 1982·Journal of Toxicology. Clinical Toxicology·M V Rudorfer
Jan 1, 1985·Drug Intelligence & Clinical Pharmacy·R J WeberD L Grysiak
Feb 1, 1980·Journal of Clinical Pharmacology·H G GilesE M Sellers
Feb 1, 1981·Clinical Toxicology·A Poklis, G E Gantner
Jan 1, 1979·Clinical Toxicology·M D AllenB J Noel
Jun 1, 1997·Journal of Clinical Psychopharmacology·J H Woods, G Winger
Aug 18, 1983·The New England Journal of Medicine·D J GreenblattD R Abernethy
Sep 2, 2006·Journal of Intensive Care Medicine·David P BettenRichard F Clark
Mar 1, 2017·Academic Forensic Pathology·Thomas P GilsonJoseph Pinjuh
Jan 1, 1979·Zeitschrift für Rechtsmedizin. Journal of legal medicine·G V Giusti, M Chiarotti
Mar 8, 1979·Zeitschrift für Rechtsmedizin. Journal of legal medicine·H J SchlichtH P Gelbke
Mar 1, 1981·The Australian and New Zealand Journal of Psychiatry·M Lader
Jan 31, 1978·Zeitschrift für Rechtsmedizin. Journal of legal medicine·H P GelbkeG Schmidt
Apr 1, 1984·Human Toxicology·D JacobsenO R Odegaard
Jan 1, 1981·Psychopharmacology·M DivollR I Shader
Mar 1, 1988·Human Toxicology·P Lheureux, R Askenasi

Related Concepts

Drug Interactions
Sedative Effect

Related Feeds


This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.