Acute oxcarbazepine, benazepril, and hydrochlorothiazide overdose with alcohol

Therapeutic Drug Monitoring
Mario FurlanutMaurizio Pecorari

Abstract

An epiletic patient, suffering from partial complex seizures and hypertension, ingested approximately 42 g of oxcarbazepine (OXC) and an undefined number of tablets containing an association of benazepril and hydrochlorothiazide along with some glasses of wine. Four hours later he was brought to the emergency room. He was stuporous and gradually became unconscious. Therefore he was intubated and, approximately 6 hours after the overdose, transferred to the intensive care unit, where he underwent a 4-hour hemodialysis. Even if this procedure did not accelerate the elimination of the prodrug nor its active metabolite (monohydrocarbazepine), 3 hours after the end of dialysis the patient was fully recovered.

References

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Citations

Jul 20, 2010·Pharmaceuticals·Matthew D Krasowski
Jun 14, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Matthew D Krasowski, Gwendolyn A McMillin
Oct 31, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marc GhannoumUNKNOWN EXTRIP workgroup
Mar 9, 2010·Thérapie·Régis BouquiéUNKNOWN le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique
Jun 26, 2009·British Journal of Clinical Pharmacology·Maura PedriniRafael Jiménez
Nov 5, 2016·Journal of Critical Care·Keaton S SmetanaDouglas R Oyler
Nov 28, 2015·Human & Experimental Toxicology·H A SpillerG Burns
Jul 30, 2021·Journal of Clinical Pharmacy and Therapeutics·Ahmet Burak DirimBahar Artim-Esen

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