PMID: 9523868Apr 2, 1998Paper

Acute pancreatitis after orthotopic liver transplantation in children: incidence, contributing factors, and outcome

Journal of Pediatric Gastroenterology and Nutrition
P TissièresD Devictor

Abstract

Acute pancreatitis after orthotopic liver transplantation is a well-known complication in adults that has never been described in children. In adults, end-stage liver disease related to hepatitis B, intraoperative pancreatic injury caused by extensive peripancreatic dissection, the type of biliary anastomosis performed, and numerous drugs, have all been described as predisposing factors in acute pancreatitis after liver transplantation. The current retrospective review was undertaken to identify the incidence, the contributing factors, and the outcome of acute pancreatitis after liver transplantation in children. During a 10-year period, 375 children underwent 434 liver transplantations in the authors' institution. In seven patients (1.9%), clinical acute pancreatitis developed after orthotopic liver transplantation. Indication for initial liver transplantation was biliary atresia (n = 3), acute liver failure (n = 3), and type 1 Crigler-Najjar syndrome. In all seven patients, liver graft function was initially adequate. The diagnosis of acute pancreatitis was based on clinical, biochemical, ultrasonographic, and surgical signs. In six patients, acute pancreatitis appeared within the first week after transplantation. The diagnos...Continue Reading

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Citations

Jul 19, 2003·Journal of Clinical Gastroenterology·Mony Benifla, Zvi Weizman
Oct 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·P TissièresD C Belli
Jan 28, 2003·Transplantation·Bijan EghtesadGeorge V Mazariegos
Jul 14, 2012·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Panagiotis VarsosNikolaos Arkadopoulos

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