Jan 2, 2007

Acute pancreatitis: animal models and recent advances in basic research

Pancreas
Yuk Cheung Chan, Po Sing Leung

Abstract

Acute pancreatitis (AP) is characterized by edema, acinar cell necrosis, hemorrhage, and severe inflammation of the pancreas. Patients with AP present with elevated blood and urine levels of pancreatic digestive enzymes, such as amylase and lipase. Severe AP may lead to systemic inflammatory response syndrome and multiorgan dysfunction syndrome, which account for the high mortality rate of AP. Although most (>80%) cases of AP are associated with gallstones and alcoholism, some are idiopathic. Although the pathogenesis of AP has not yet been elucidated, a common feature is the premature activation of trypsinogen within pancreatic tissues, which triggers autodigestion of the gland. Recent advances in basic research suggest that etiologic factors including cyclooxygenase-2, substance P, and angiotensin II may have novel roles in this disease. Basic research data obtained thus far have been based on animal models of AP ranging from mild edematous pancreatitis to severe necrotizing pancreatitis. In view of this, an adequate selection of experimental animal models is of paramount importance. Notwithstanding these animal models, it should be emphasized that none of these models mimic the clinical situation where varying degrees of sev...Continue Reading

  • References153
  • Citations84

References

Mentioned in this Paper

Urine Level Measurement
Pathogenic Aspects
Cyclooxygenase 2
Necrosis
Pathogenesis
Systemic Inflammatory Response Syndrome
Acute Pancreatitis
Pancreatitis
Benign Tumor of Pancreas
Alcoholic Intoxication, Chronic

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