Acute pancreatitis associated with intravenous administration of propofol: evaluation of causality in a systematic review of the literature

Gastroenterology Report
Samir HaffarFateh Bazerbachi

Abstract

Acute pancreatitis (AP) associated with intravenous administration of propofol has been described with unknown causal relation. We therefore assessed this causality in a systematic review. Multiple databases were searched on 16 August 2017; studies were appraised and selected by two reviewers based on a priori criteria. Propofol causality was evaluated with the Naranjo scale and Badalov classification. We identified 18 studies from 11 countries with a total of 21 patients, and the majority had adequate methodological quality. The median age was 35 years (range, 4-77) and 10 (48%) were males. Overall, propofol was administrated in 8 patients as sedative along with induction/maintenance of anesthesia in 13 patients; median dose was 200 mg, with intermediate latency (1-30 days) in 14 (67%). Serum triglycerides were >1000 mg/dL in four patients. Severe AP was observed in four patients (19%). AP recurrence occurred in one out of two patients who underwent rechallenge. Mortality related to AP was 3/21(14%). Propofol was the probable cause of AP according to the Naranjo scale in 19 patients (89%). Propofol-induced AP has a probable causal relation and evidence supports Badalov class Ib. Hypertriglyceridemia is not the only mechanism b...Continue Reading

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Citations

Oct 29, 2019·Current Cancer Drug Targets·Milad AshrafizadehSaeed Samarghandian
Dec 5, 2020·Critical Care Explorations·Michael J CorradoJeremy R DeGrado
Jan 26, 2021·Critical Care Explorations·Mary P KovacevicJeremy R DeGrado
Feb 18, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Samir HaffarFateh Bazerbachi
Aug 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Boghuma K TitanjiVincent C Marconi
Aug 27, 2021·Clinical Journal of Gastroenterology·Yu AkazawaYasunari Nakamoto

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