Acute pancreatitis associated with lisinopril and olanzapine

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Jesse D BracamontePaul Sarmiento

Abstract

A case of acute pancreatitis associated with lisinopril and olanzapine is described. A 69-year-old woman came to the emergency department after four days of experiencing epigastric pressurelike pain that radiated to the left lower quadrant and worsened with ingestion of food. She had started lisinopril three months prior for treatment of hypertension and had been taking olanzapine regularly for bipolar disorder. Upon admission, she was afebrile and hemodynamically stable and exhibited tenderness of the epigastric region. Elevated pancreatic enzymes and abdominal computed tomography (CT) imaging findings confirmed the diagnosis of pancreatitis. Common causes of pancreatitis were ruled out, and it was determined that the recent combination of lisinopril and olanzapine was the likely cause. Food and liquids were withheld, and all oral medications were stopped at hospital admission. Her pain resolved completely after two days. She was discharged on hospital day 4, and all of her medications except lisinopril and olanzapine were resumed. During a follow-up visit with her primary care physician, she reported to be doing well and had no systemic complaints. Olanzapine was reinitiated at that time but was discontinued a month later by ...Continue Reading

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Citations

Feb 9, 2012·Current Gastroenterology Reports·Claudia NitscheJulia Mayerle
Feb 6, 2016·Journal of Clinical Psychopharmacology·Libor UstohalTomas Kasparek
Jul 26, 2017·Der Nervenarzt·M Hahn, S C Roll

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