Mar 27, 2009

Acute pancreatitis: etiology and common pathogenesis

World Journal of Gastroenterology : WJG
Guo-Jun WangSi-Qin Ding

Abstract

Acute pancreatitis is an inflammatory disease of the pancreas. The etiology and pathogenesis of acute pancreatitis have been intensively investigated for centuries worldwide. Many causes of acute pancreatitis have been discovered, but the pathogenetic theories are controversial. The most common cause of acute pancreatitis is gallstone impacting the distal common bile-pancreatic duct. The majority of investigators accept that the main factors for acute billiary pancreatitis are pancreatic hyperstimulation and bile-pancreatic duct obstruction which increase pancreatic duct pressure and active trypsin reflux. Acute pancreatitis occurs when intracellular protective mechanisms to prevent trypsinogen activation or reduce trypsin activity are overwhelmed. However, little is known about the other acute pancreatitis. We hypothesize that acute biliary pancreatitis and other causes of acute pancreatitis possess a common pathogenesis. Pancreatic hyperstimulation and pancreatic duct obstruction increase pancreatic duct pressure, active trypsin reflux, and subsequent unregulated activation of trypsin within pancreatic acinar cells. Enzyme activation within the pancreas leads to auto-digestion of the gland and local inflammation. Once the hyp...Continue Reading

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References

Mentioned in this Paper

Pathogenic Aspects
Sialadenitis
Pathogenesis
Acute Pancreatitis
Acinar Cell of Pancreas
Protoplasm
Pancreatitis
Benign Tumor of Pancreas
Inflammatory Disorder
Acute Disease

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