Acute panmyelosis with myelofibrosis: clinical, immunophenotypic and cytogenetic study of twelve cases

Leukemia & Lymphoma
N SuvajdzicM Colovic

Abstract

The clinical, cytogenetic, and immunophenotypic features in 12 adult patients with acute panmyelosis with myelofibrosis (APMF; ICD-0-3: 9931/3; C42.1) are reported (median age: 57 years; f/m = 1.4). The white cell count (WBC) was normal in 3 patients; 9 had leucopenia. The median hemoglobin value was 64.5 g/l, and median platelet count 12 x 10(9)/l. Bone marrow biopsy showed a hypercellular marrow in 10/12 patients with a significant infiltration of pathological blasts (range: 30 - 60%). All the cases had marked reticulin fibrosis. Immunophenotyping of bone marrow blast cells showed the expression of early (CD34) and lineage-unspecified antigens (HLA-DR) in 6/7, and 7/7 patients, respectively. "Early" myeloid antigens (CD13, CD33) were seen in 6/7 and 4/6 patients respectively. Monocyte antigen (CD14) was expressed in 3/7 patients. Megakaryocyte antigen (CD61) and erythroid cell antigen (GpA) were each expressed in only 1 patient. Two patients had expression of CD34, HLA-DR and "early" myeloid antigens by their bone marrow blast cells and 1 of these also had a co-expression of the antigens from a differentiated monocytic cell proliferation (lysozyme+, CD68+). Nonspecific chromosomal aberrations were recorded in 8/10 patients. T...Continue Reading

References

Jan 1, 1979·Cancer·R M BearmanH Rappaport
Oct 1, 1979·British Journal of Haematology·A ManoharanW R Pitney
Jan 1, 1990·Leukemia Research·F OrtuñoN Pujol-Moix
Dec 1, 1989·Cancer Genetics and Cytogenetics·E OláhA Kiss
Jul 1, 1984·Scandinavian Journal of Haematology·J ThieleA Georgii
Jun 1, 1982·American Journal of Clinical Pathology·N ClareL Manhoff
Jun 1, 1994·Cancer Genetics and Cytogenetics·A NovakV Jurukovski
May 1, 1996·Cancer Genetics and Cytogenetics·L MichauxH Van Den Berghe
Aug 1, 1996·Cancer Genetics and Cytogenetics·E F AllenR E Branda
Jan 13, 2000·American Journal of Clinical Pathology·B Krishnan, L D Truong
Jul 8, 2000·American Journal of Clinical Pathology·N KraguljacM Colovic
Jul 28, 2001·Archives of Pathology & Laboratory Medicine·C H DunphyL J Gardner
Feb 15, 2002·Clinical and Laboratory Haematology·B J BainUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology (BCSH), British Society of Haematology
Sep 20, 2002·Blood·James W VardimanRichard D Brunning

❮ Previous
Next ❯

Citations

Oct 27, 2009·The American Journal of Medicine·Priscilla Kaliopi BrastianosMichael Streiff
Nov 2, 2014·Cytometry. Part B, Clinical Cytometry·Linlin WangWeina Chen
Apr 29, 2016·Journal of Community Hospital Internal Medicine Perspectives·Aditya GoudStephen Selinger
Jul 28, 2019·Leukemia·Milena PanticAnnette Schmitt-Graeff
Mar 8, 2021·Pathology·Tracy I George, Ashish Bajel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.