Acute paretic syndrome in juvenile White Leghorn chickens resembles late stages of acute inflammatory demyelinating polyneuropathies in humans.

Journal of Neuroinflammation
Sophie R BaderKaspar Matiasek

Abstract

Sudden limb paresis is a common problem in White Leghorn flocks, affecting about 1% of the chicken population before achievement of sexual maturity. Previously, a similar clinical syndrome has been reported as being caused by inflammatory demyelination of peripheral nerve fibres. Here, we investigated in detail the immunopathology of this paretic syndrome and its possible resemblance to human neuropathies. Neurologically affected chickens and control animals from one single flock underwent clinical and neuropathological examination. Peripheral nervous system (PNS) alterations were characterised using standard morphological techniques, including nerve fibre teasing and transmission electron microscopy. Infiltrating cells were phenotyped immunohistologically and quantified by flow cytometry. The cytokine expression pattern was assessed by quantitative real-time PCR (qRT-PCR). These investigations were accomplished by MHC genotyping and a PCR screen for Marek's disease virus (MDV). Spontaneous paresis of White Leghorns is caused by cell-mediated, inflammatory demyelination affecting multiple cranial and spinal nerves and nerve roots with a proximodistal tapering. Clinical manifestation coincides with the employment of humoral immu...Continue Reading

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Citations

Sep 4, 2013·BioMed Research International·Kishan Kumar Nyati, Roopanshi Nyati
Feb 14, 2012·Clinical Neuroradiology·M NichtweissE Hattingen
Jun 7, 2020·BMC Veterinary Research·Mohan AcharyaNarayan C Rath
May 11, 2018·Avian Pathology : Journal of the W.V.P.A·Sesny GallIsabel M Gimeno

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Methods Mentioned

BETA
transmission electron microscopy
electron microscopy
flow cytometry
FCS
PCR
genotyping
electrophoresis

Software Mentioned

AvIDP
LOGISTIC
PrimerExpress
FlowJo

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