Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary infection: a case report

BMC Gastroenterology
Laurent SpahrJacques Schrenzel

Abstract

Splanchnic vein thrombosis may complicate inherited thrombotic disorders. Acute cytomegalovirus infection is a rare cause of acquired venous thrombosis in the portal or mesenteric territory, but has never been described extending into a main hepatic vein. A 36-year-old immunocompetent woman presented with acute primary cytomegalovirus infection in association with extensive thrombosis in the portal and splenic vein. In addition, a fresh thrombus was evident in the right hepatic vein. A thorough evaluation for a hypercoagulable state was negative. The clinical course, biological evolution, radiological and histological findings were consistent with cytomegalovirus hepatitis complicated by a partial acute Budd-Chiari syndrome and portal thrombosis. Therapeutic anticoagulation was associated with a slow clinical improvement and partial vascular recanalization. We described in details a new association between cytomegalovirus infection and acute venous thrombosis both in the portal vein and in the right hepatic vein, realizing a partial Budd-Chiari syndrome. One should be aware that this rare thrombotic event may be complicated by partial venous outflow block.

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Citations

Jan 1, 2009·Journal of Thrombosis and Thrombolysis·Antonio Mendoza LaddLarry DiFabrizio
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A SquizzatoN Brumana
Aug 19, 2007·The American Journal of the Medical Sciences·Zvi G FridlenderEran Leitersdorf
Feb 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara BelgaCarlos Cervera
Jan 19, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Manuela CeccarelliGiuseppe Nunnari
Dec 30, 2020·BMJ Case Reports·Caroline BurkeyJames Sabetta

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Methods Mentioned

BETA
flow cytometry
PCR
biopsy
contraception

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