Nov 9, 2007

Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats

Experimental Brain Research
Nicola SimolaM Herrera-Marschitz

Abstract

A large body of clinical evidence suggests a possible association between perinatal asphyxia and the onset of early, as well as long-term, neurological and psychiatric disorders including cognitive deficits. The present study investigated cognitive and motor function modifications in a well characterized and clinically relevant experimental rat model of human perinatal asphyxia. The results reported here show that adult rats exposed to a single (20 min) asphyctic episode at delivery displayed: (a) a deficit in non-spatial memory, assessed in a novel object recognition task; (b) an impaired motor coordination, measured by the rotarod test. On the other hand, gross motor activity and spatial memory, evaluated in both the Y maze and the Barnes maze, were not affected by perinatal asphyxia. The results of this study provide further insights into the long-term effects of perinatal asphyxia on neurobehavioural functions.

Mentioned in this Paper

Molecular Motor Activity
Memory Loss
Fetishism (Psychiatric)
Acute Disease
Motor Function
Cognition Disorders
Psychiatry Specialty
Psychomotor Performance
Age Factors
Rats, Wistar

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