Acute phase protein concentrations predict parasite clearance rate during therapy for visceral leishmaniasis

Transactions of the Royal Society of Tropical Medicine and Hygiene
K M WasunnaK P McAdam

Abstract

Visceral leishmaniasis (VL) remains a major health problem in Kenya and other parts of Africa, Central America and Asia. Currently, splenic aspirate smear and culture are the standard methods of monitoring therapy and relapse. Acute phase reactant markers, C-reactive protein (CRP), serum amyloid A protein (SAA) and alpha 1-acid glycoprotein (AGP) were evaluated as less invasive techniques for monitoring therapy in 59 patients with VL before, during and after therapy. CRP, SAA and AGP were elevated in VL patients at admission and the concentrations decreased with effective therapy to reach normal levels by the end of therapy (SAA and AGP) or by 3 months follow-up (CRP). Two groups of patients were selected on the basis of rate of parasite clearance. The acute phase protein concentrations were significantly raised in those slower to clear parasites. Analysis of sensitivity and specificity of acute phase proteins as predictors of parasite clearance suggested that they might represent useful non-invasive markers for monitoring disease activity, response to therapy and relapse in VL.

References

Mar 1, 1991·Journal of Clinical Pathology·S H GillespieK P McAdam
Mar 1, 1986·Annals of Tropical Paediatrics·M AdhikariA Moosa
Sep 1, 1989·The American Journal of Tropical Medicine and Hygiene·Y MebrahtuC Roberts
Jan 1, 1985·World Health Organization Technical Report Series
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Naik, A Voller
Mar 1, 1983·The American Journal of Tropical Medicine and Hygiene·L K LightnerA D Bryceson
May 1, 1983·The American Journal of Tropical Medicine and Hygiene·J D Chulay, A D Bryceson
Jul 1, 1993·The Journal of Clinical Investigation·H W GhalibS G Reed
May 1, 1993·The American Journal of Tropical Medicine and Hygiene·K E SquiresH W Murray
Apr 1, 1993·The Journal of Clinical Investigation·D M VigushinP N Hawkins
Sep 30, 1930·The Journal of Experimental Medicine·W S Tillett, T Francis

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Citations

May 5, 2010·Veterinary Research Communications·D BrittiG Cuda
Apr 20, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Claudia M C GomesCarlos E P Corbett
Sep 13, 2011·Clinical Proteomics·Lokesh A RukmangadacharAlagiri Srinivasan
Aug 21, 2003·American Journal of Veterinary Research·Silvia Martínez-SubielaJosé J Cerón
Jul 9, 2010·Gerodontology·Masayuki KanekoHideo Miyazaki
Nov 28, 2013·The Journal of Small Animal Practice·R O LealL Tavares
Nov 5, 2014·Antimicrobial Agents and Chemotherapy·Anke E KipThomas P C Dorlo
Aug 23, 2016·International Journal of Molecular Sciences·Patrícia Sampaio Tavares Veras, Juliana Perrone Bezerra de Menezes
Sep 15, 2005·Annals of Tropical Paediatrics·Luis E Cuevas, Ai Koyanagi
Aug 31, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Carlos Henrique Nery CostaLoryenne Santos Santos
Jul 22, 2017·PLoS Neglected Tropical Diseases·Fitsumbrhan TajebePascale Kropf
Sep 29, 2020·Parasite Immunology·Simone S LimaDorcas Lamounier Costa
Mar 28, 2002·The Veterinary Record·S Martínez-SubielaJ J Cerón

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