Acute phase protein response during subclinical infection of pigs with H1N1 swine influenza virus

Veterinary Microbiology
Małgorzata Pomorska-MólZygmunt Pejsak

Abstract

In the present study acute phase proteins (APPs) responses in pigs after subclinical infection with H1N1 swine influenza virus (SwH1N1) were evaluated. Fourteen 5 weeks old, seronegative piglets, both sexes were used. Ten of them were infected intranasally with SwH1N1. C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA) and pig major acute phase protein (Pig-MAP) concentrations in serum were measured using commercial ELISAs. No significant clinical signs were observed in any of the infected pigs, however, all infected animals developed specific antibodies against SwH1N1 and viral shedding was observed from 2 to 5 dpi. Only concentrations of Hp and SAA were significantly induced after infection, with mean maximum levels from days 1 to 2 post infection (dpi). The concentrations of CRP and Pig-MAP remained generally unchanged, however in half of infected pigs the concentration of CRP tended to increase at 1 dpi (but without statistical significance). The results of our study confirmed that monitoring of APPs may be useful for detection of subclinically infected pigs. The use of SAA or Hp and Pig-MAP may be a valuable in combination [i.e. Hp (increased concentration) and Pig-MAP (unchanged concentration)] to detect su...Continue Reading

References

May 26, 2004·The Veterinary Journal·H MurataM Yoshioka
Jun 16, 2006·Veterinary Immunology and Immunopathology·N S SorensenP M H Heegaard
Nov 25, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M D ParraJ J Cerón
Jan 26, 2010·The Veterinary Journal·Filip BarbéKristien Van Reeth
Apr 20, 2011·Veterinary Immunology and Immunopathology·Iwona Markowska-DanielZygmunt Pejsak
Jun 1, 2006·The Veterinary Quarterly·H KothalawalaE Gruys

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Citations

May 23, 2014·Archives of Virology·Małgorzata Pomorska-MólZygmunt Pejsak
Mar 26, 2013·Molecular Immunology·Elisa CrisciMaria Montoya
Nov 21, 2012·Research in Veterinary Science·Yongqian YangDeli Zhang
Nov 19, 2013·Veterinary Microbiology·Elisa CrisciMaria Montoya
Jun 20, 2017·Developmental and Comparative Immunology·Héctor CorderoAlberto Cuesta
Apr 16, 2014·Influenza and Other Respiratory Viruses·Małgorzata Pomorska-MólIwona Markowska-Daniel

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