Acute-phase proteins and microalbuminuria among patients with type 2 diabetes

Diabetes Research and Clinical Practice
M B Gomes, V G Nogueira

Abstract

to determine the relationship between acute-phase proteins and microalbuminuria in type 2 diabetic patients without clinical evidence of macrovascular disease. We studied cross-sectionally 64 non-smoking outpatients with type 2 diabetes mellitus without clinical evidence of cardiovascular disease attended at Brazilian University General Hospital aged 59.5 +/- 8.1 years and with a known duration of diabetes of 11.5 +/- 8 years. Urinary albumin excretion rate (AER) was determined in timed overnight urine samples. Serum alpha(1)-acid glycoprotein (AGP) and plasma fibrinogen were determined by immunoturbidimetry assay and serum C-reactive protein (CRP) was measured by a high-sensitive immunonephelometry assay. A higher levels of AGP (P = 0.0000), CRP (P= 0.003) and fibrinogen ( P = 0.0001) were found in microalbuminuric (n = 26) than in normoalbuminuric patients ( n = 38). All the acute-phase proteins were correlated with each other and with AER, respectively (r = 0.67 for AGP; 0.35 for fibrinogen, and 0.41 for CRP, P < 0.01 for all). Stepwise multiple regression analysis showed that AGP was independently associated with AER along with systolic blood pressure (r2 = 0.49, P = 0.000). Logistic regression analysis showed that AGP was ...Continue Reading

References

Sep 1, 1991·The Journal of Clinical Investigation·P De FeoM W Haymond
Jan 1, 1996·Diabetes Care·A A Alzaid
Mar 1, 1997·Journal of Diabetes and Its Complications·P Kilaru, G L Bakris
Nov 5, 1998·Diabetes Care·E RaynaudJ Mercier
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Jan 5, 2000·Journal of Diabetes and Its Complications·M Rodríguez-Morán, F Guerrero-Romero
Jun 17, 2000·Atherosclerosis·E RaynaudJ Mercier
Oct 4, 2003·Diabetes & Metabolism·M B GomesH J Matos

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Citations

Feb 17, 2009·Pediatric Research·Michiko SuzukiHermine I Brunner
Oct 17, 2015·Expert Review of Molecular Diagnostics·George MermelekasJerome Zoidakis
Jul 18, 2008·Diabetes Research and Clinical Practice·I-Te LeeWayne H-H Sheu
Aug 23, 2008·Prostaglandins & Other Lipid Mediators·Marilia de Brito GomesEduardo Tibiriçá
May 29, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ai-Hui LiangZhi-Liang Jiang
Aug 23, 2005·Diabetes/metabolism Research and Reviews
Jan 12, 2007·Periodontology 2000·Fusanori NishimuraYoshihiko Soga
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Sep 8, 2007·European Journal of Internal Medicine·Sahar S BessaEhab M M Ali
Apr 1, 2007·Proteomics. Clinical Applications·Eun-Hee ChoChan-Wha Kim
Oct 28, 2017·Diabetology & Metabolic Syndrome·Mayara Karla Dos Santos NunesDarlene Camati Persuhn
Jun 19, 2018·Frontiers in Endocrinology·Lauren WinterElif I Ekinci
May 28, 2005·Biological Research for Nursing·Jessica M GillGayle G Page

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