Acute phase proteins, C-reactive protein and serum amyloid A protein, as prognostic markers in the elderly inpatient

Age and Ageing
M B HogarthM B Pepys

Abstract

to study the clinical significance and potential utility of measuring serum amyloid A protein (SAA) compared with the classical acute phase protein, C-reactive protein (CRP). a 3 month prospective study on 66 women, mean age 83 years (range 69-106) and 33 men, mean age 84 years (range 69-95), admitted to the geriatric medicine unit at Hammersmith Hospital. CRP and SAA were determined on admission and at intervals throughout hospital stay; outcome end-points were death during the study, detection of infection, duration of admission and early re-admission to hospital after discharge. CRP and SAA responses were highly correlated (r = 0.75, P = 0.0001). However, the SAA response was greater than that of CRP in most individuals, with a median ratio of initial SAA to CRP of 2.2 in patients with infective pathology and 1.6 in those with inflammatory pathology. Median (range) SAA on admission was 98 (0.1-940) mg/ml in patients with infection and was twice that observed in patients with other causes of inflammation, median value 50 (0.6-699) mg/l. There was no difference between median CRP on admission in patients with infection or inflammation, median value 53 (0.1-235) and 51.5 (5-246) mg/l respectively. Initial and peak levels of CRP...Continue Reading

Citations

Feb 12, 2004·The Lancet Infectious Diseases·Jean-Paul Janssens, Karl-Heinz Krause
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Jan 15, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ayumi TobaHideki Takahashi
Aug 19, 2008·Immunity & Ageing : I & a·Astrid L WesterTorgeir Bruun Wyller
Jul 25, 2012·Annals of Intensive Care·Pedro Póvoa, Jorge I F Salluh
Apr 26, 2006·Critical Care : the Official Journal of the Critical Care Forum·Pedro PóvoaHenrique Sabino
Jun 16, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·T Yamada
May 9, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·I GlojnarićJ Lukac
Apr 18, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Martin SchillingerErich Minar
Sep 12, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Martin SchillingerErich Minar
Dec 24, 2004·Srpski arhiv za celokupno lekarstvo·Dijana B Jovanović
Apr 11, 2012·Polski przeglad chirurgiczny·Andrzej WitczakMałgorzata Gawlik
Nov 1, 2002·The Lancet Infectious Diseases·Gaëtan Gavazzi, Karl-Heinz Krause
May 1, 2009·Médecine et maladies infectieuses·P-M RogerE Cua
Oct 3, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ferdinando CogheVassilios Fanos
Oct 23, 2015·Expert Review of Anti-infective Therapy·Ligia S C F RabelloJorge If Salluh
Apr 19, 2005·Expert Review of Molecular Diagnostics·Bruce H Davis
Jul 15, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Małgorzata Pomorska-MólZygmunt Pejsak
May 6, 2008·Archives of Gerontology and Geriatrics·Christine ForasassiAgathe Raynaud-Simon
Aug 5, 2005·Journal of the American Geriatrics Society·Fabien StuckerGaëtan Gavazzi
Aug 29, 2012·FEMS Immunology and Medical Microbiology·Małgorzata Pomorska-MólKrzysztof Kwit
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A Raynaud-SimonY Le Bouc
Jul 19, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pedro PóvoaUNKNOWN Portuguese Community-Acquired Sepsis Study Group SACiUCI
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·E S Nylén, A A Alarifi
Mar 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Pierre DamasJean-Charles Preiser
Feb 1, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P PóvoaH Sabino
Jul 4, 2008·PLoS Medicine·Marie-Louise DalyBabak Javid
Sep 2, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Halil YamanKemal M Erbil
Dec 22, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Marian KacerovskyCtirad Andrys
Sep 30, 2005·The American Journal of Pathology·Huijun SunJianglin Fan
Sep 7, 2016·European Journal of Internal Medicine·Andrea TicinesiTiziana Meschi
Feb 1, 2013·Therapeutic Advances in Infectious Disease·João Gonçalves-PereiraPedro Póvoa
Sep 1, 2017·Aging Clinical and Experimental Research·Omer KarasahinSevnaz Sahin
May 7, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Catharina M PetersMichael A Echteld
Jun 28, 2020·Experimental Gerontology·Anders KarlsenMichael Kjaer

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