Nov 15, 1977

Acute-phase proteins from the liver and enzymes from myocardial infarction; a quantitative relationship

Clinica Chimica Acta; International Journal of Clinical Chemistry
S J SmithJ Gerbrandy

Abstract

In 14 patients with acute myocardial infarction (M.I.) not having any other disease, the possible quantitative relationship between enzymes from M.I. and changes in concentration of acute phase reactants coming from the liver were studied. The patients were followed up until 1 1/2 years after M.I. and comparison of baseline-protein values took place using a control group of 18 healthy individuals. Quantitation of protein changes was done by planimetric determination of the area under the concentration curve and by taking peak values. The myocardial infarction was quantitatively estimated by mathematical analysis of the time course of alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) plasma concentrations and by taking peak values. A quantitative relationship with enzymatic infarct size was found for haptoglobin, alpha1-acid glycoprotein, alpha1-antitrypsin, C-reactive protein, fibrinogen and E.S.R. Albumin and transferrin did not show a negative quantitative relationship with enzymatic infarct size. Humoral factors originating from the site of tissue injury and evoking in proportion a positive acute phase reaction by the liver are probably the basis for this observed quantitative relationship.

  • References12
  • Citations23

References

  • References12
  • Citations23

Citations

Mentioned in this Paper

Acute-Phase Reaction
SERPINA1 gene
C-reactive Protein Measurement
HP gene
Enzymes, antithrombotic
Fibrinogen
Fibrinogen Assay
Glycoproteins
Transferrin
Gene Products, Protein

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