PMID: 2478287Sep 15, 1989Paper

[Acute phase proteins in acute myocardial infarct].

Casopís lékar̆ů c̆eských
J KrcmováB Fixa

Abstract

The authors investigated changes of proteins of the acute stage (transferrin, prealbumin, orosomucoid, alpha-1 antitrypsin) after the development of acute coronaries. Blood specimens were collected from 84 patients with the diagnosis of acute myocardial infarction (AMI) on the 1st, 3rd, 7th and 21st day of hospitalization. The authors observed a significant reduction of transferrin and prealbumin values on the third day after the development of AMI and a significant rise with a maximum on the 7th day in orosomucoid and alpha-1 antitrypsin (p less than 0.05). The assessed changes are consistent with data reported in the literature. When the patients were divided into groups with AMI type Q and AMI type non Q, the authors observed a significant rise of alpha-1 antitrypsin on the 7th day in group AMI type Q (p less than 0.01). In patients with AMI type non Q alpha-1 antitrypsin was within the normal range, while in group AMI type Q it was on the 3rd and 7th day beyond the normal range. In the remaining proteins of the acute stage no significant differences were found on comparison of the two groups.

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