Abstract
Acute inflammatory processes can trigger increased production of acute phase proteins (APPs) that can be useful biomarkers of inflammation. APPs are diverse and include proteins involved in coagulation, opsonization, iron regulation, and limitation of tissue injury. Haptoglobin, serum amyloid A, and alpha-1 acid glycoprotein have been proposed as useful APPs in goats. APPs can differ markedly by species, therefore species-specific reference intervals and studies are necessary. The objective of this study was to determine species-specific reference intervals for 4 APPs in goats. Haptoglobin, serum amyloid A, lipopolysaccharide binding protein, and alpha-1 acid glycoprotein were measured in in 54 clinically normal adult goats. APPs were measured using goat-specific commercial enzyme-linked immunosorbent assay kits. Results were analyzed by 1-way analysis of variance to compare sexes and breeding status. Reference Value Advisor was used to calculate reference limits according to the IFCC-CLSI guidelines. Only 1 APP was found to vary in healthy animals; serum haptoglobin was increased in lactating animals and decreased in pregnant does in their second trimester when compared with open, nonlactating does. No sex-based differences we...Continue Reading
References
Apr 12, 1979·Nature·F P NoonanG J Clunie
Oct 1, 1993·The Journal of Veterinary Medical Science·E UchidaK Takahashi
May 5, 1998·Fundamental & Clinical Pharmacology·E M MuchitschL Pichler
Feb 24, 2001·The Veterinary Record·P D EckersallJ L Fitzpatrick
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua FiererDouglas Golenbock
Feb 21, 2003·The Journal of Biological Chemistry·Nicolas W J SchröderRalf R Schumann
Dec 3, 2003·The Journal of Dairy Research·Ulrika GrönlundKarin Persson Waller
Feb 13, 2004·The Journal of Veterinary Medical Science·Jacky Peng-Wen ChanShuang Lin Lee
May 26, 2004·The Veterinary Journal·H MurataM Yoshioka
Jul 22, 2004·Veterinary Parasitology·R M KaplanA F Vatta
Mar 21, 2006·Electrophoresis·Fausto CairoliElisabetta Gianazza
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·F L A C MestrinerF Q Cunha
Sep 9, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Félix H D GonzálezJosé J Cerón
Jan 11, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Félix H D GonzálezFernando Tecles
Mar 4, 2011·Veterinary Clinical Pathology·Anne GeffréCatherine Trumel
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·A M GutiérrezS Martínez-Subiela
Dec 18, 2012·Veterinary Clinical Pathology·Kristen R FriedrichsUNKNOWN American Society for Veterinary Clinical Pathology
Mar 19, 2013·Journal of Dairy Science·Z Olumee-ShabonJ L Boehmer
Sep 17, 2013·Clinics·Romualdo Barroso-SousaAntonio Pazin-Filho
May 24, 2014·Animal : an International Journal of Animal Bioscience·Y Y JiaX Z Shen
Citations
Jun 24, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Michał CzopowiczJarosław Kaba
Oct 4, 2017·Acta Veterinaria Scandinavica·Michał CzopowiczJarosław Kaba
Jul 21, 2020·Journal of Dairy Science·A CabidduE Trevisi
Mar 27, 2018·Journal of Dairy Science·Melissa N HempsteadMhairi A Sutherland
Nov 15, 2018·Veterinary Research·Daria ReczyńskaEmilia Bagnicka
Jun 19, 2020·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Kristen TobinCarolyn Cray
Dec 3, 2020·Animals : an Open Access Journal From MDPI·Ayla Del RomeroMónica Rubio