Acute-phase reaction induced by zoledronate and its effect on prognosis of patients with advanced non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Hiroki IzumiEiji Shimizu

Abstract

Zoledronate (ZOL) is usually used for prevention of skeletal-related events in cancer patients with bone metastases. The first administration of ZOL is occasionally associated with development of acute-phase reaction (APR), which is due to activation of γδ T cells. ZOL-related APR was associated with better overall survival (OS) of patients with non-small cell lung cancer (NSCLC) in our previous retrospective study. However, it remains to be clarified whether γδ T cells are more activated in patients who experienced ZOL-related APR, and whether γδ T cell activation is involved in prolongation of OS. Twenty-three patients with advanced NSCLC were recruited between 2012 and 2014 in this study. We administered ZOL to participants with standard care. The patient characteristics, change in γδ T cell counts and cytokines, OS, and skeletal-related event-free survival were compared between patients with APR (APR group) and those without APR (non-APR group). Ten patients (43.5%) experienced a ZOL-related APR. The number of γδ T cells at baseline in the APR group was significantly higher than that in the non-APR group. Serum interleukin-6 and tumor necrosis factor-α in the APR group were significantly increased, but no change in the numb...Continue Reading

References

Mar 6, 1999·The New England Journal of Medicine·V KunzmannM Wilhelm
Dec 4, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giordano DicuonzoGiuseppe Tonini
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tetsuya MitsudomiYasushi Yatabe
Jul 28, 2006·Current Opinion in Immunology·Marc Bonneville, Emmanuel Scotet
Sep 13, 2007·Medical Oncology·Agustin AvilésJudith Huerta-Guzmán
Feb 14, 2009·The New England Journal of Medicine·Michael GnantC Marth
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Kostantinos ZarogoulidisNikos K Karamanos
Jun 18, 2010·The Journal of Clinical Endocrinology and Metabolism·I R ReidD M Black
Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Haruhiko NakamuraShinobu Tatsunami
Oct 1, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maurizio RossiniDavide Gatti
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Nov 16, 2012·Cancer Immunology, Immunotherapy : CII·Tomoharu SugieYoshimasa Tanaka
Jul 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistMartin Schuler
May 23, 2014·JAMA : the Journal of the American Medical Association·Mark G KrisPaul A Bunn
Feb 17, 2015·Pharmaceuticals·Hirohito Kobayashi, Yoshimasa Tanaka
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 22, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chee Khoon LeeJames Chih-Hsin Yang

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Citations

Sep 29, 2020·Lung Cancer : Targets and Therapy·Wang YangJiuwei Cui
Mar 26, 2020·Annals of the New York Academy of Sciences·Ibrahim T FazminKamalan Jeevaratnam
Apr 30, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Meng QiaoCaicun Zhou

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