PMID: 2496517Mar 11, 1989Paper

Acute phase response in horses: changes in plasma cation concentrations after localised tissue injury

The Veterinary Record
D E AuerA A Seawright

Abstract

An acute phase reaction was elicited in four horses to which Freund's adjuvant was administered intramuscularly. The localised inflammation was accompanied by changes in the plasma concentrations of copper, iron and zinc. The plasma copper concentration, the plasma ceruloplasmin copper concentration and the ceruloplasmin oxidase activity in the plasma steadily increased to a maximum 24 days after the administration of the adjuvant. At this time, the plasma copper concentration was 2.2 micrograms/ml, a 90 per cent increase over the baseline concentration. The ratio of the concentration of plasma ceruloplasmin copper to plasma copper remained constant, indicating that the non-ceruloplasmin bound copper component of the plasma is also an acute phase reactant in the horse. The plasma zinc and iron concentrations decreased to 59 per cent and 30 per cent of their respective baseline concentrations and the severity of the inflammation appeared to influence the plasma concentrations of each metal. Weak correlations between the plasma fibrinogen concentration and the plasma copper and zinc concentrations of 25 horses with plasma fibrinogen concentrations of 5 g/litre or greater indicated that a single measurement of plasma copper concen...Continue Reading

Citations

Oct 8, 2009·The Journal of Biological Chemistry·Carine WhiteMichael J Petris
Mar 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·I J VisserE Gruys
Dec 31, 1997·Equine Veterinary Journal·P C MillsD E Auer
Sep 14, 2012·The Journal of Veterinary Medical Science·Harutaka MuraseYasuo Nambo
Aug 14, 2009·Veterinary Surgery : VS·Stine JacobsenMartin Bang Thoefner
Aug 15, 2015·Journal of Veterinary Emergency and Critical Care·Alexander J DanielDiana M Hassel
Sep 20, 2011·Innate Immunity·José P Oliveira-FilhoAlexandre S Borges
Dec 1, 2009·Veterinary Immunology and Immunopathology·José P Oliveira FilhoAlexandre S Borges
Dec 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·P C MillsD E Auer
Jun 17, 2006·Chest·Yuh-Chin T HuangAndrew J Ghio
Feb 6, 2015·Metallomics : Integrated Biometal Science·Erik Ladomersky, Michael J Petris
Jun 11, 1998·Equine Veterinary Journal·S G PearceP F Fennessy
Mar 6, 2012·The Journal of Biological Chemistry·Victoria Hodgkinson, Michael J Petris
Aug 31, 1996·The Veterinary Record·P C Mills, D J Marlin
Sep 18, 2001·Equine Veterinary Journal·G StarkM Gemeiner
Apr 26, 2005·The Veterinary Record·P J PollockC R Bellenger
May 26, 2004·The Veterinary Journal·H MurataM Yoshioka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.