Acute-phase response in rat to carbon tetrachloride-azathioprine induced cirrhosis and partial hepatectomy of cirrhotic liver

Journal of Toxicology and Environmental Health
F M FouadF Shahidi

Abstract

Irreversible liver cirrhosis was induced in rats by supplementing their diet with 0.02% azathioprine and intubating them twice a week with carbon tetrachloride in corn oil. Over period of 3 mo, intoxicated rats showed an atypical acute-phase reaction (APR). The relative concentrations of haptoglobin, beta-lipoprotein, alpha-1-antitrypsin, an unknown peak "X, " and transferrin increased exponentially following a mild initial drop, while albumin, C3c + C3, alpha-1-acid glycoprotein, alpha-1-lipoprotein, and macroglobulin declined continually during the experiment. The accumulated peritoneal fluid was found to contain a similar spectrum of APR proteins. On the other hand, histological examination revealed gradual liver damage manifested as a gradual increase in the areas of collagen separating liver cells, and at the end of the experiment, severe liver damage was evident with isolated hepatocytes in a matrix of collagen. The available data point to the disparity that exists between the physical status of hepatocytes and their biochemical function, which suggests that the remaining metabolically fatigued hepatocytes of the cirrhotic liver continue to biosynthesize and release elevated concentrations of some secretable APR proteins ...Continue Reading

Citations

Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Hernández-MuñozV C De Sánchez
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Man ChenHui Wang
Sep 28, 2004·Journal of Cellular Biochemistry·Apolinar Maya-MendozaArmando Aranda-Anzaldo
Oct 13, 2005·Phytotherapy Research : PTR·M A RusuMihaela Sabadas
Aug 1, 1996·Medical Hypotheses·F M FouadF Shahidi

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