Acute phase responses after acute liver injury by partial hepatectomy in rats as indicators of cytokine release

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
R P Cornell

Abstract

The purpose of this study was to support the hypothesis that cytokines such as interleukin-1, tumor necrosis factor and interleukin-6 are released by macrophages or monocytes within 1 to 2 hr of phagocytosis of circulating, gut-derived bacterial lipopolysaccharide translocated by acute liver injury. Time courses of fever, neutrophilia and low blood-zinc levels generally attributed to cytokines were quantified after partial (67%) hepatectomy of rats under ether anesthesia. These acute phase responses in hepatectomized rats were compared with those after intravenous injection of exogenous endotoxin and human natural interleukin-1. Fever commenced 30 min after interleukin-1 injection, 4 hr after exogenous lipopolysaccharide injection and 6 hr after 67% liver resection. Similarly, rectal temperatures were significantly elevated in recipient rats 30 min after intravenous administration of donor plasma from hepatectomized animals, indicating that cytokines, not lipopolysaccharide, elicited the febrile response. Neutrophilia was present 1, 2, and 4 hr after interleukin-1 injection, lipopolysaccharide injection and hepatectomy, respectively. Furthermore, the reduction in plasma zinc, which depends on cellular metallothionein synthesis,...Continue Reading

References

Jul 1, 1979·The Journal of Surgical Research·Y SakamotoD M Hays
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Dec 1, 1975·Journal of Cellular Physiology·R H Rixon, J F Whitfield
Oct 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J Cousins, A S Leinart
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L Thiele
Apr 1, 1989·The American Journal of Physiology·H D KimJ H Im
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C J McClain, D A Cohen
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F KatsumotoF Nakayama
Aug 14, 1987·Biochemical and Biophysical Research Communications·A UeharaA Arimura
Sep 1, 1988·Digestive Diseases and Sciences·J A Jorge-HernandezL Hernandez-Nieto
Mar 30, 1987·Biochemical and Biophysical Research Communications·G ScalabrinoA Bernelli-Zazzera
Jun 16, 1988·Biochemical and Biophysical Research Communications·K R FeingoldC Grunfeld
Apr 1, 1988·Gastroenterology·C AnastassakosR Williams
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SabatiniG R Mundy
Mar 1, 1988·Gastroenterology·S J van DeventerG N Tytgat
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LumsdenM H Kutner
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Oct 20, 1986·Life Sciences·C J McClainA M Kaplan
Dec 1, 1986·Infection and Immunity·P GhezziC A Dinarello
Oct 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·R F Kampschmidt, T Jones
Oct 1, 1985·Molecular and Cellular Biology·M KarinG Wong
Oct 1, 1985·The Biochemical Journal·P S SchofieldM C Sugden
Dec 1, 1985·Journal of Applied Physiology·J T StittH A Bernheim
Jul 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·D A UcarM J Kluger
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A CuthbertB Combes
Jan 1, 1982·Immunological Reviews·S B Mizel
May 6, 1983·Science·J G Cannon, M J Kluger
Aug 1, 1982·The Journal of Surgical Research·R A KeenanB R Bistrian
Jul 31, 1980·Biochemical and Biophysical Research Communications·M PrestaG Ragnotti

❮ Previous
Next ❯

Citations

Dec 17, 2004·Proteomics·Christoph W StreyJohn D Lambris
Oct 1, 1996·Digestive Diseases and Sciences·Y ShiratoriM Omata
Nov 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·I V PliushchD N Maianskiĭ
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S UenoT Aikou
May 27, 2005·The Journal of Surgical Research·Hirochika MakinoHiroshi Shimada
Jul 1, 1996·Journal of Hepatology·K P de JongO T Terpstra
Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H TryphonasR Mehta
Jun 30, 1998·Transplantation·S S YadavP A Clavien
Mar 23, 2006·Annals of Surgery·Martin J SchindlStephen J Wigmore
Jun 13, 2000·American Journal of Veterinary Research·M J BaarschM P Murtaugh
Jun 9, 2001·Biochemical and Biophysical Research Communications·G M HurJ H Lee
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiaki ShimizuM Wayne Flye
Sep 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Jun 20, 2008·The British Journal of Surgery·J E SlottaH Thorlacius
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L LaskinJ D Laskin
Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A BoermeesterP A van Leeuwen
Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K R FeingoldC Grunfeld
Nov 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C TohyamaH Nishimura
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carolina ArmengolGabriel Capellá

❮ Previous
Next ❯

Related Concepts

Related Feeds