Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model

Toxicon : Official Journal of the International Society on Toxinology
Mónica PradoBruno Lomonte

Abstract

Bee stings are a health concern in the Americas, where fatal envenomings due to massive attacks by Africanized honeybees have been documented in the last decades. Most studies on the toxic effects of honeybee venom in experimental animals have been performed using the intravenous or intraperitoneal injection routes. The aim of this study was to develop a mouse model that would better resemble a massive honeybee attack by using the subcutaneous (s.c.) route to induce a severe, sublethal systemic envenoming. An array of acute venom effects were characterized, including biochemical, hematological, histological, and inflammatory alterations, after the s.c. injection of 0.5 median lethal dose of venom. Rapid increases in serum alanine (ALT) and aspartate (AST) transaminases, creatinine, urea nitrogen, uric acid, sodium and chloride electrolytes, and creatine kinase (CK) were recorded, indicating damage to liver, kidneys, and skeletal muscle. Also, coagulation disturbances (fibrinogen decrease, and moderate delay in prothrombin and partial thromboplastin times) were demonstrated. Circulating platelet and leukocyte numbers remained unaltered, but a hemoconcentration effect (hematocrit and hemoglobin increase) was observed. This effect...Continue Reading

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Citations

Jan 21, 2014·Journal of Ethnopharmacology·Angel Josabad Alonso-Castro
Mar 29, 2013·Journal of the American Animal Hospital Association·Emily ThomasLori S Waddell
Feb 2, 2016·Toxicon : Official Journal of the International Society on Toxinology·Gabriela PessendaJosé E Barbosa
Dec 26, 2015·Toxicon : Official Journal of the International Society on Toxinology·Goran GajskiVera Garaj-Vrhovac
Jun 26, 2012·Environmental and Molecular Mutagenesis·Goran GajskiVera Garaj-Vrhovac
Mar 29, 2016·Toxicon : Official Journal of the International Society on Toxinology·Paloma L SousaAna Maria S Assreuy
Mar 12, 2013·Toxicon : Official Journal of the International Society on Toxinology·Camila Z El-KikPaulo A Melo
Jun 20, 2017·Toxicon : Official Journal of the International Society on Toxinology·Elisane Lenita MilbradtRaphael Lucio Andreatti Filho
Apr 21, 2018·American Journal of Hematology·Elisabeth FarhatEmmanuel J Favaloro
Nov 8, 2011·World Journal of Hepatology·Adel Nazmi AlqutubAhmed Alomair
Jan 16, 2017·Kidney International·Emmanuel A Burdmann, Vivekanand Jha
Jul 28, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Qianqian HanZewen Liu
Jul 24, 2021·Wilderness & Environmental Medicine·Dong LaiChing-Feng Weng

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